MABE126
抗-SR蛋白家族抗体（克隆16H3）
clone 16H3, from mouse
别名:
splicing factor, arginine/serine-rich 6, arginine/serine-rich splicing factor 6, splicing factor, arginine/serine-rich, 55 kDa, Pre-mRNA-splicing factor SRP55, pre-mRNA splicing factor SRP55
产品名称
抗-SR蛋白家族抗体（克隆16H3）, clone 16H3, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
16H3, monoclonal
species reactivity
human
species reactivity (predicted by homology)
mouse (based on 100% sequence homology), rat (based on 100% sequence homology)
technique(s)
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SRSF6(6431)
Physical form
蛋白G纯化
形式：纯化
纯化的小鼠单克隆IgG1κ，溶于含0.1 M Tris-甘氨酸（pH 7.4），150 mM NaCl和0.05％叠氮化钠的缓冲液中。
Preparation Note
自收到之日起，在2-8°C条件下可稳定保存1年。
Analysis Note
对照
HeLa核提取物
HeLa核提取物
通过蛋白质印迹对HeLa核提取物进行了评估。
蛋白质印迹分析：0.5 µg/mL的该抗体在10 µg HeLa核提取物中检测到SR 蛋白。
蛋白质印迹分析：0.5 µg/mL的该抗体在10 µg HeLa核提取物中检测到SR 蛋白。
Application
免疫沉淀分析： 一个代表性批次被独立实验室用于进行IP（Neugebauer, KM, et al. (1995)）
免疫细胞化学分析： 一个代表性批次已被独立实验室用于IC。(Neugebauer, KM, et al. (1995).
免疫细胞化学分析： 一个代表性批次已被独立实验室用于IC。(Neugebauer, KM, et al. (1995).
抗-SR蛋白家族抗体（克隆16H3）是小鼠单克隆抗体，用于检测SR蛋白家族（也称为富含丝氨酸/精氨酸剪接因子6），& 已在WB、IP、ICC中得到验证。
研究子类别
RNA代谢&结合蛋白
RNA代谢&结合蛋白
研究类别
表观遗传学&核功能
表观遗传学&核功能
Biochem/physiol Actions
该抗体可识别四种核蛋白SRp75、SRp55、SRp40和 SRp20，以及20多种对应于SR家族的其它主要核蛋白。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
多个 SR家族成员被检测到。据报道主要检测到SRp75、SRp55、SRp40、SRp30、SRp20 （Neugebauer, KM, et al. (1995)
富含Ser-Arg(SR)的蛋白质构成功能和结构上保守的磷蛋白家族，并且是替代性和组成性pre-mRNA剪接的必需组成部分。SR蛋白的特征在于其模块化组成由两个目标结构域组成:用于确定DNA结合特异性的N末端RNA识别基序(RRM)和RS结构域（富含精氨酸和丝氨酸的C末端结构域，充当SR蛋白的穿梭和定位导向器以及剪接激活结构域。它们参与前mRNA剪接的各个方面和剪接体组装，包括；剪接位点的识别和分配，以及选择性剪接调控的操纵。
Immunogen
去磷酸化牛SRp55 和GST标记重组去磷酸化SRp55 （Neugebauer, KM et. al 1995）
Other Notes
浓度：请参考批次特异性浓缩物的检验报告。
未找到合适的产品？
试试我们的产品选型工具.
存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
María Luz Morales et al.
Leukemia, 37(8), 1649-1659 (2023-07-09)
Despite the approval of several drugs for AML, cytarabine is still widely used as a therapeutic approach. However, 85% of patients show resistance and only 10% overcome the disease. Using RNA-seq and phosphoproteomics, we show that RNA splicing and serine-arginine-rich
Morgane Corre et al.
Nucleic acids research, 51(22), 12459-12475 (2023-11-09)
Cell autonomous responses to intracellular bacteria largely depend on reorganization of gene expression. To gain isoform-level resolution of these modes of regulation, we combined long- and short-read transcriptomic analyses of the response of intestinal epithelial cells to infection by the
Komal Raina et al.
Nucleus (Austin, Tex.), 13(1), 58-73 (2022-03-01)
Nuclear Speckles (NS) are phase-separated condensates of protein and RNA whose components dynamically coordinate RNA transcription, splicing, transport and DNA repair. NS, probed largely by imaging studies, remained historically well known as Interchromatin Granule Clusters, and biochemical properties, especially their
Tyler Funnell et al.
Nature communications, 8(1), 7-7 (2017-02-25)
CDC-like kinase phosphorylation of serine/arginine-rich proteins is central to RNA splicing reactions. Yet, the genomic network of CDC-like kinase-dependent RNA processing events remains poorly defined. Here, we explore the connectivity of genomic CDC-like kinase splicing functions by applying graduated, short-exposure
Antonella Pinto et al.
British journal of pharmacology, 172(11), 2918-2927 (2015-01-28)
Dehydroepiandrosterone (DHEA) is thought to be an anti-glucocorticoid hormone known to be fully functional in young people but deficient in aged humans. Our previous data suggest that DHEA not only counteracts the effect of cortisol on RACK1 expression, a protein
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持