MABN15
抗-视紫红质抗体，克隆4D2
clone 4D2, from mouse
别名:
rhodopsin, rhodopsin (opsin 2, rod pigment) (retinitis pigmentosa 4, autosomal dominant), retinitis pigmentosa 4, autosomal dominant, opsin 2, rod pigment
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
4D2, monoclonal
Application:
ELISA
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Species reactivity:
rat, human, fish
Citations:
38
Technique(s):
ELISA: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
Uniprot accession no.:
产品名称
抗-视紫红质抗体，克隆4D2, clone 4D2, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
4D2, monoclonal
species reactivity
rat, human, fish
species reactivity (predicted by homology)
mouse (based on 100% sequence homology)
technique(s)
ELISA: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
isotype
IgG2bκ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... RHO(6010)
rat ... Rho(24717)
Analysis Note
对照
大鼠眼组织
大鼠眼组织
通过免疫组织化学在大鼠眼组织中进行评价。
免疫组织化学分析：该抗体以1:500稀释度在大鼠眼组织中检测到视紫红质。
免疫组织化学分析：该抗体以1:500稀释度在大鼠眼组织中检测到视紫红质。
Application
抗视紫红质抗体，克隆4D2是抗视紫红质的抗体，用于IH、WB、IC、ELISA。
研究子类别
感官 & PNS
感官 & PNS
研究类别
神经科学
神经科学
蛋白质印迹分析： 根据Knight K等人的报告，该抗体的一个先前批次通过WB在金鱼视网膜裂解物中检测到视紫红质。
免疫细胞化学： 根据Knight K等人的报告，该抗体的一个先前批次通过ICC在金鱼视网膜组织中检测到视紫红质。
免疫组织化学分析：该抗体以1:500稀释度已显示检测到人眼组织中的视紫红质。
ELISA： 根据Laird D等人的报告，在竞争性ELISA中验证了来自不同批次的该抗体的特异性。
免疫细胞化学： 根据Knight K等人的报告，该抗体的一个先前批次通过ICC在金鱼视网膜组织中检测到视紫红质。
免疫组织化学分析：该抗体以1:500稀释度已显示检测到人眼组织中的视紫红质。
ELISA： 根据Laird D等人的报告，在竞争性ELISA中验证了来自不同批次的该抗体的特异性。
Biochem/physiol Actions
该抗体识别N末端的视紫红质。
Disclaimer
除非我们的目录或产品随附的其他公司文件中另有说明，否则我们的产品预期仅用于研究用途，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或对人类或动物的任何类型的消费或应用。
General description
视紫红质是属于G蛋白偶联受体1家族的多通道G蛋白偶联膜受体蛋白。视紫红质在视杆细胞中发现，被光子激活，以使视觉转导级联初始化。视紫红质对于在弱光下形成图像以及出生后感光细胞的生存能力是必需的。视紫红质表达的突变是人类疾病色素性视网膜炎(RP)的最广为人知的原因，导致视力逐渐丧失。目前，已知的视紫红质突变超过100种。
预期在~39 kDa处
Immunogen
对应于N末端的大鼠视紫红质的大鼠视网膜感光细胞外节膜盘。
表位：N末端
Other Notes
浓度：关于批次特定浓度请参见检验报告。
Physical form
形式：纯化
纯化的小鼠单克隆IgG2bκ，溶于含0.1 M Tris-甘氨酸（pH 7.4）、150 mM NaCl和0.05％叠氮化钠的缓冲液中。
纯化蛋白G
Preparation Note
自接收之日起，在2-8°C下可稳定保存1年。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Zhe Zhang et al.
The Journal of biological chemistry, 295(34), 12153-12166 (2020-07-09)
Pheromones play critical roles in habitat identification and reproductive behavior synchronization in the sea lamprey (Petromyzon marinus). The bile acid 3-keto petromyzonol sulfate (3kPZS) is a major component of the sex pheromone mixture from male sea lamprey that induces specific
Liang Jia et al.
The Journal of biological chemistry, 297(5), 101268-101268 (2021-10-04)
Biogenic amines activate G-protein-coupled receptors (GPCRs) in the central nervous system in vertebrate animals. Several biogenic amines, when excreted, stimulate trace amine-associated receptors (TAARs), a group of GPCRs in the main olfactory epithelium, and elicit innate behaviors. How TAARs recognize
Kayvan Samimi et al.
Biomedical optics express, 13(6), 3476-3492 (2022-07-06)
Photoreceptors are the key functional cell types responsible for the initiation of vision in the retina. Phototransduction involves isomerization and conversion of vitamin A compounds, known as retinoids, and their recycling through the visual cycle. We demonstrate a functional readout
Roni A Hazim et al.
Experimental eye research, 179, 18-24 (2018-10-20)
Human RPE cell lines, especially the ARPE-19 cell line, are widely-used in eye research, as well as general epithelial cell studies. In comparison with primary RPE cells, they offer relative convenience and consistency, but cultures derived from these lines are typically
Devi Krishna Priya Karunakaran et al.
Investigative ophthalmology & visual science, 56(2), 787-798 (2015-01-17)
To understand how loss of citron kinase (CitK) affects retinal progenitor cells (RPCs) in the developing rat retina. We compared knockout (KO) and wild-type (WT) retinae by immunohistochemistry. The TdT-mediated dUTP terminal nick-end labeling (TUNEL) assay was performed to determine
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