biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
3D9, monoclonal
species reactivity
rat
species reactivity (predicted by homology)
human (immunogen homology)
technique(s)
immunocytochemistry: suitable, western blot: suitable
isotype
IgMκ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... DRD2(1813)
rat ... Drd2(24318)
General description
中枢神经系统多巴胺能系统的问题被认为是某些神经精神疾病的根本原因。多巴胺D2受体是多巴胺的五种类型（D1至D5）受体之一。该受体的活性由抑制腺苷酸环化酶的G蛋白介导。使用Nurr1和ERK的多巴胺D2受体信号传导可能在中脑多巴胺能神经元发育中起重要作用。有缺陷的D2受体在ROS依赖性高血压病例中很常见。此外，DRD2的缺陷与酒精反应性肌张力障碍，对家族性酒精中毒的易感性不同以及酗酒者自杀风险的促成因素有关。
观测分子量〜50 kDa
Immunogen
对应于人多巴胺D2受体的线性肽。
Application
免疫细胞化学分析：独立实验室使用了一个先前批次来检测Ntera-2细胞和大鼠脑神经元中的多巴胺D2受体。 由Wolfson Centre for Inherited Neuromuscular Disease的Glenn Morris提供。
经验证，该抗多巴胺D2受体（DRD2）抗体（克隆2B9）可用于检测多巴胺D2受体（DRD2）的WB、IC。
Physical form
形式：纯化
Analysis Note
对照
大鼠脊髓组织裂解物
大鼠脊髓组织裂解物
通过蛋白质印迹法在大鼠脊髓组织裂解物中进行评估。
蛋白质印迹分析：5 µg/mL的该抗体在10 µg大鼠脊髓组织裂解物上检测到多巴胺D2受体。
蛋白质印迹分析：5 µg/mL的该抗体在10 µg大鼠脊髓组织裂解物上检测到多巴胺D2受体。
Other Notes
Still not finding the right product?
试用我们的 产品选型工具 工具缩小选择范围
存储类别
12 - Non Combustible Liquids
wgk
WGK 1
Dasiel O Borroto-Escuela et al.
Neurotoxicity research, 37(2), 433-444 (2019-11-30)
Cocaine was previously shown to act at the Sigma1R which is a target for counteracting cocaine actions. It therefore becomes of interest to test if the monoamine stabilizer (-) OSU-6162 (OSU-6162) with a nanomolar affinity for the Sigma1R can acutely
Dasiel O Borroto-Escuela et al.
Frontiers in molecular neuroscience, 16, 1106765-1106765 (2023-06-09)
Previous studies have indicated that acute treatment with the monoamine stabilizer OSU-6162 (5 mg/kg), which has a high affinity for Sigma1R, significantly increased the density of accumbal shell D2R-Sigma1R and A2AR-D2R heteroreceptor complexes following cocaine self-administration. Ex vivo studies using
Wilber Romero-Fernandez et al.
Molecular neurobiology, 59(10), 5955-5969 (2022-07-14)
The adenosine A2A receptor (A2AR), dopamine D2 receptor (D2R) and metabotropic glutamate receptor type 5 (mGluR5) form A2AR-D2R-mGluR5 heteroreceptor complexes in living cells and in rat striatal neurons. In the current study, we present experimental data supporting the view that
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| MABN53 | 04053252523847 |