MABN832

抗-pan-AMPA受体（GluR1-4），克隆2D8抗体

Name: 抗-pan-AMPA受体（GluR1-4），克隆2D8抗体
Brand: MM

clone 2D8, from mouse

别名:

Glutamate receptor 1, GluR-1, AMPA-selective glutamate receptor 1, GluR-A, GluR-K1, Glutamate receptor ionotropic, AMPA 1, GluA1

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关于此项目

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Conjugate:

unconjugated

Clone:

2D8, monoclonal

Application:

ELISA
electron microscopy
immunocytochemistry
immunofluorescence
immunohistochemistry
western blot

Species reactivity:

human, rat

Citations:

Technique(s):

ELISA: suitable
electron microscopy: suitable
immunocytochemistry: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
western blot: suitable

Uniprot accession no.:

P42261
P42262
P42263
P48058

主要文件

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产品名称

抗-pan-AMPA受体（GluR1-4），克隆2D8抗体, clone 2D8, from mouse

biological source

mouse

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

2D8, monoclonal

species reactivity

human, rat

technique(s)

ELISA: suitable
electron microscopy: suitable
immunocytochemistry: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
western blot: suitable

isotype

IgG2bκ

NCBI accession no.

NP_000817
NP_000818
NP_000819
NP_000820

UniProt accession no.

P42261
P42262
P42263
P48058

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... GRIA1(2890)

Analysis Note

通过蛋白质印迹法在大鼠脑组织裂解物中进行评价。

蛋白质印迹分析：0.5 µg/mL的该抗体在10 µg大鼠脑组织裂解物中检测到AMPA受体（GluR1-4）。

Application

抗泛AMPA受体（GluR1-4），克隆2D8抗体是抗AMPA受体的抗体，用于蛋白质印迹、免疫组织化学和免疫细胞化学、酶免疫测定(ELISA)、电子显微镜和免疫荧光。

蛋白质印迹分析：0.5 µg/mL的代表性批次在10 µg人脑组织裂解物中检测到AMPA受体（GluR1-4）。
蛋白质印迹分析：1.0 µg/mL的代表性批次在10 µg转染的人GluA1 HEK293、转染的大鼠GluA1 HEK293、转染的大鼠GluA2 HEK293、转染的大鼠GluA3 HEK293和模拟转染的细胞裂解物中检测到AMPA受体（GluR1-4）。
免疫组织化学分析：一个代表性批次以1:250-1,000稀释度在人大脑皮层、人丘脑、大鼠小脑和大鼠大脑皮层组织中检测到AMPA受体（GluR1-4）。
免疫细胞化学分析：一个代表性批次在转染了GluA1、GluA2、GluA3和GluA4的Hela细胞中检测到AMPA受体（GluR1-4）（由Mount Sinai School of Medicine的John Morrison博士提供）。
免疫荧光分析：一个代表性批次在啮齿动物、灵长类动物和人脑切片中检测到AMPA受体（GluR1-4）（由Mount Sinai School of Medicine的John Morrison博士提供）。
电子显微镜分析：一个代表性批次在大鼠海马中检测到AMPA受体（GluR1-4）（由Mount Sinai School of Medicine的John Morrison博士提供）。
ELISA分析：一个代表性批次在TrpE融合蛋白中检测到AMPA受体（GluR1-4）（由Mount Sinai School of Medicine的John Morrison博士提供）。

General description

观测分子量〜85 kDa。某些裂解物中可能会出现未表征的条带。

谷氨酸受体是主要位于神经元细胞膜上的突触受体。在配体刺激后，离子型谷氨酸受体（iGluRs）形成非选择性阳离子通道，而代谢型谷氨酸受体（mGluRs）通过G蛋白介导的信号传导间接激活离子通道。AMPA受体是iGluR，也称为α-氨基-3-羟基-5-甲基-4-异恶唑丙酸受体，AMPAR或使君子氨酸受体。AMPAR由四种类型的亚基组成，GluR1/GluA1（UniProt P42261）由GRIA1编码、GluR2/GluA2（UniProt P42262）由GRIA2编码、GluR3/GluA3（UniProt P42263）由GRIA3编码，以及GluR4/GluA4（UniProt P48058）由GRIA4编码人体内的基因。AMPAR本质上是四聚体，由两组同型二聚体组成，最常见的是一组GluR2二聚体与一组GluR1、GluR3或GluR4同型二聚体偶联。目录号抗pan-AMPA受体（GluR1-4），克隆2D8与所有四个AMPA受体亚基反应。

Immunogen

编码对应于人泛AMPA受体（GluR1-4）的AMPA谷氨酸受体1-4的胞外域的融合蛋白。

Other Notes

浓度：请参考特定批次的数据表。

Physical form

形式：纯化

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存储类别

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Mitochondrial ROS control neuronal excitability and cell fate in frontotemporal dementia.

Noemí Esteras et al.

Alzheimer's & dementia : the journal of the Alzheimer's Association, 18(2), 318-338 (2021-06-01)

The second most common form of early-onset dementia-frontotemporal dementia (FTD)-is often characterized by the aggregation of the microtubule-associated protein tau. Here we studied the mechanism of tau-induced neuronal dysfunction in neurons with the FTD-related 10+16 MAPT mutation. Live imaging, electrophysiology

AMPA-Type Glutamate Receptors Associated With Vascular Smooth Muscle Cell Subpopulations in Atherosclerosis and Vascular Injury.

Alessandro L Gallina et al.

Frontiers in cardiovascular medicine, 8, 655869-655869 (2021-05-08)

Objectives and Aims: Vascular smooth muscle cells (VSMCs) are key constituents of both normal arteries and atherosclerotic plaques. They have an ability to adapt to changes in the local environment by undergoing phenotypic modulation. An improved understanding of the mechanisms

Behavioural impairments after exposure of neonatal mice to propofol are accompanied by reductions in neuronal activity in cortical circuitry.

Hang Zhou et al.

British journal of anaesthesia, 126(6), 1141-1156 (2021-03-02)

Both animal and retrospective human studies have linked extended and repeated general anaesthesia during early development with cognitive and behavioural deficits later in life. However, the neuronal circuit mechanisms underlying this anaesthesia-induced behavioural impairment are poorly understood. Neonatal mice were

Ferric Chelate Reductase 1 Like Protein (FRRS1L) Associates with Dynein Vesicles and Regulates Glutamatergic Synaptic Transmission.

Wenyan Han et al.

Frontiers in molecular neuroscience, 10, 402-402 (2017-12-26)

In the brain, AMPA receptors (AMPARs)-mediated excitatory synaptic transmission is critically regulated by the receptor auxiliary subunits. Recent proteomic studies have identified that Ferric Chelate Reductase 1 Like protein (FRRS1L), whose mutations in human lead to epilepsy, choreoathetosis, and cognitive

抗-pan-AMPA受体（GluR1-4），克隆2D8抗体

clone 2D8, from mouse

选择尺寸

关于此项目

主要文件

属性

产品名称

biological source

conjugate

antibody form

antibody product type

clone

species reactivity

technique(s)

isotype

NCBI accession no.

UniProt accession no.

shipped in

target post-translational modification

Quality Level

Gene Information

相关类别

说明

Analysis Note

Application

General description

Immunogen

Other Notes

Physical form

安全信息

存储类别

wgk

flash_point_f

flash_point_c

文件

分析证书(COA)

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