MABN88
抗-K+/Cl-协同转运蛋白（KCC2）抗体，克隆N1/12
clone N1/12, from mouse
别名:
Electroneutral potassium-chloride cotransporter 2, Erythroid K-Cl cotransporter 2, Neuronal K-Cl cotransporter, electroneural potassium-chloride cotransporter 2, solute carrier family 12, potassium-chloride transporter), member 5
产品名称
抗-K+/Cl-协同转运蛋白（KCC2）抗体，克隆N1/12, clone N1/12, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
N1/12, monoclonal
species reactivity
rat, human
technique(s)
immunohistochemistry: suitable
isotype
IgG2aκ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SLC12A5(57468)
rat ... Slc12A5(171373)
Analysis Note
对照
大鼠皮质A-3区组织
大鼠皮质A-3区组织
通过免疫组织化学在大鼠皮质A-3区组织中进行评估。
免疫组织化学分析：该抗体以1:300稀释度在大鼠皮质区域A-3组织中检测到KCC2。
免疫组织化学分析：该抗体以1:300稀释度在大鼠皮质区域A-3组织中检测到KCC2。
Application
使用经验证可用于IH的抗K+/Cl-协同转运蛋白（KCC2）抗体（克隆N1/12）检测K+/Cl-协同转运蛋白（KCC2）。
免疫组织化学分析：一个先前批次以1:300稀释度在大鼠下丘脑组织中检测到KCC2。
研究子类别
离子通道&转运蛋白
离子通道&转运蛋白
研究类别
神经科学
神经科学
Biochem/physiol Actions
由一个独立的实验室显示在人和小鼠组织中发生反应。（UC Davis/NIH NeuroMab Facility，神经生物学、生理学和行为学系）
该抗体识别KCC2
Disclaimer
除非我们的目录或产品随附的其他公司文件中另有说明，否则我们的产品预期仅用于研究用途，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或对人类或动物的任何类型的消费或应用。
General description
KCC2是阳离子-氯化物共转运蛋白基因家族的成员。它充当K-Cl共转运蛋白。KCC通常将细胞内氯化物的浓度降低到电化学平衡电位以下，并且取决于钾和氯化物的化学浓度梯度，KCC2可以作为净流出或流入途径起作用。提出其充当主要的氯化物挤出剂，以促进大脑中快速超极化的突触后抑制。KCC2在整个神经系统的神经元中高水平表达，免疫荧光显示该蛋白位于脊髓的抑制性突触处。在小鼠中的研究表明，KCC2降低了GABA′s抑制性信号传导，导致运动缺陷、癫痫和焦虑样行为。
计算分子量126 kDa
Immunogen
对应于大鼠KCC2的重组蛋白。
表位：未知
Other Notes
浓度：关于批次特定浓度请参见检验报告。
Physical form
形式：纯化
纯化的小鼠单克隆IgG2aκ，溶于含0.1 M Tris-甘氨酸（pH 7.4，150 mM NaCl）和0.05%叠氮化钠的缓冲液中。
蛋白G
Preparation Note
自接收之日起，在2-8°C下可稳定保存1年。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Daniella Thorsdottir et al.
Journal of neurophysiology, 126(4), 1209-1220 (2021-08-19)
Presympathetic neurons in the paraventricular nucleus of the hypothalamus (PVN) play a key role in cardiovascular regulation. We have previously shown that brain-derived neurotrophic factor (BDNF), acting in the PVN, increases sympathetic activity and blood pressure and serves as a
Marika Markkanen et al.
The Journal of comparative neurology, 522(8), 1897-1914 (2014-03-19)
The neuronal K-Cl cotransporter KCC2 maintains the low intracellular chloride concentration required for the fast hyperpolarizing actions of inhibitory neurotransmitters in mature central nervous system (CNS). The KCC2 gene produces two isoforms, KCC2a and KCC2b, that differ in their N-termini.
Sana Al Awabdh et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 42(2), 166-182 (2021-11-24)
The K+-Cl- cotransporter KCC2, encoded by the Slc12a5 gene, is a neuron-specific chloride extruder that tunes the strength and polarity of GABAA receptor-mediated transmission. In addition to its canonical ion transport function, KCC2 also regulates spinogenesis and excitatory synaptic function
Yuansong Wan et al.
The Journal of cell biology, 222(2) (2022-12-10)
Epilepsy is a common neurological disease worldwide, and one of its causes is genetic abnormalities. Here, we identified a point mutation in KIF4A, a member of kinesin superfamily molecular motors, in patients with neurological disorders such as epilepsy, developmental delay
Vladimir Jovasevic et al.
Nature neuroscience, 18(9), 1265-1271 (2015-08-19)
Fear-inducing memories can be state dependent, meaning that they can best be retrieved if the brain states at encoding and retrieval are similar. Restricted access to such memories can present a risk for psychiatric disorders and hamper their treatment. To
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