MABS276
抗-pan聚甘氨酸化微管蛋白抗体，克隆AXO 49
clone AXO 49, from mouse
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
AXO 49, monoclonal
Species reactivity:
Apis, porcine, snail, pig, sea urchin, protista, sheep, mouse, lemur, Drosophila, Paramecium, trout
Application:
dot blot
immunofluorescence
western blot
immunofluorescence
western blot
Technique(s):
dot blot: suitable
immunofluorescence: suitable
western blot: suitable
immunofluorescence: suitable
western blot: suitable
Citations:
17
产品名称
抗-pan聚甘氨酸化微管蛋白抗体，克隆AXO 49, clone AXO 49, from mouse
biological source
mouse
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
AXO 49, monoclonal
species reactivity
Apis, porcine, snail, pig, sea urchin, protista, sheep, mouse, lemur, Drosophila, Paramecium, trout
should not react with
Euglena, human (cilia)
technique(s)
dot blot: suitable
immunofluorescence: suitable
western blot: suitable
isotype
IgG1κ
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... TUBA1A(7846)
Analysis Note
通过蛋白质印迹法评估草履虫的总细胞骨架蛋白。：该抗体以1:50,000稀释度在10 µg草履虫总细胞骨架蛋白中检测到聚糖基化微管蛋白。
Application
使用该小鼠单克隆抗体（抗泛聚甘氨酰化微管蛋白抗体，克隆AXO 49，经验证可用于蛋白质印迹和免疫荧光&斑点印迹）检测微管蛋白。
Biochem/physiol Actions
该抗体可识别含有至少3个甘氨酸残基的聚合物的侧向连接分支。该抗体与聚甘氨酰化微管蛋白以及其他聚甘氨酰化蛋白具有交叉反应性。
General description
已经在真核细胞中鉴定了微管蛋白的几种翻译后修饰。 糖基化是一种多修饰，其发生在纤毛草履虫的轴丝微管蛋白中鉴定的可变长度的甘氨酸链的侧向分支中。已经在许多单细胞和多细胞生物的微管蛋白和/或纤毛/鞭毛上检测到这种修饰。细胞质和轴丝室之间不同的聚糖基化微管蛋白亚型的差异分布表明，微管蛋白的聚糖基化水平在细胞水平上受到高度调节。AXO49抗体主要对运动性纤毛和鞭毛的轴丝微管蛋白具有反应性，这些纤毛和鞭毛被聚甘氨酰化。在某些情况下，还可以在其他非常稳定的微管网络上观察到反应性。该抗体可用于纤毛和鞭毛检测。
观测分子量〜55 kDa
Immunogen
草履虫纤毛（草履虫轴丝）的不溶性部分
Other Notes
浓度：关于批次特定浓度请参见检验报告。
Physical form
形式：纯化
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Suzanne H Hodge et al.
Biology open, 10(8) (2021-08-07)
Primary cilia are compartmentalised from the rest of the cell by a ciliary gate comprising transition fibres and a transition zone. The ciliary gate allows the selective import and export of molecules such as transmembrane receptors and transport proteins. These
Harrison D Pravder et al.
International journal of molecular sciences, 23(6) (2022-03-26)
A useful model for determining the mechanisms by which actin and actin binding proteins control cellular architecture is the Drosophila melanogaster process of spermatogenesis. During the final step of spermatogenesis, 64 syncytial spermatids individualized as stable actin cones move synchronously
Jennifer Lennon et al.
Frontiers in genetics, 13, 943197-943197 (2022-07-26)
Axonemal dynein motors are large multi-subunit complexes that drive ciliary movement. Cytoplasmic assembly of these motor complexes involves several co-chaperones, some of which are related to the R2TP co-chaperone complex. Mutations of these genes in humans cause the motile ciliopathy
Haibo Xie et al.
Journal of molecular cell biology, 14(7) (2022-08-19)
Meiosis is essential for evolution and genetic diversity in almost all sexual eukaryotic organisms. The mechanisms of meiotic recombination, such as synapsis, have been extensively investigated. However, it is still unclear whether signals from the cytoplasm or even from outside
Abdullah O Khan et al.
Haematologica, Online ahead of print (2020-12-18)
In specialised cells, the expression of specific tubulin isoforms and their subsequent post-translational modifications drive and coordinate unique morphologies and behaviours. The mechanisms by which β1-tubulin, the platelet and megakaryocyte (MK) lineage restricted tubulin isoform, drives platelet production and function
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