产品名称
抗-线性泛素抗体，克隆LUB9, clone LUB9, from mouse
antibody product type
primary antibodies
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
clone
LUB9, monoclonal
species reactivity
human
technique(s)
western blot: suitable
isotype
IgG2bκ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... UBC(7316)
Analysis Note
通过蛋白质印迹法在重组蛋白线性多聚泛素链、K48 Ub 2-7、K63 Ub 2-7和仅K11的Ubn泛素化HM底物蛋白中进行评估。
蛋白质印迹分析：1.0 µg/mL该抗体检测到10 µg线性多聚泛素重组蛋白链，在K48 Ub 2-7、K63 Ub 2-7和仅K11的Ubn泛素化HM底物蛋白中未检测到条带。
蛋白质印迹分析：1.0 µg/mL该抗体检测到10 µg线性多聚泛素重组蛋白链，在K48 Ub 2-7、K63 Ub 2-7和仅K11的Ubn泛素化HM底物蛋白中未检测到条带。
Application
抗线性泛素抗体，克隆LUB9 | MABS451是抗线性泛素抗体的抗体，用于蛋白质印迹。
研究子类别
信号神经科学
信号神经科学
研究类别
信号传导
信号传导
蛋白质印迹分析：一个代表性批次在（M1连接）泛素链中检测到线性泛素（Yoshiteru，S.et al.（2013）.EMBO.32:2463-2476）。
Biochem/physiol Actions
该抗体仅检测线性泛素。
Disclaimer
除非我们的目录或产品随附的其他公司文件中另有说明，否则我们的产品预期仅用于研究用途，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或对人类或动物的任何类型的消费或应用。
General description
泛素作为标志物发挥作用，指示细胞中其他蛋白质的命运。它可以作为单个分子或多聚泛素链连接。尽管泛素化的蛋白质通常会被20S蛋白酶体标记为降解，但泛素化也可能表明其他命运，具体取决于将泛素链连接至目标蛋白质所涉及的赖氨酸残基。通过Lys33连接到激酶底物（例如AMP激活的蛋白激酶（AMPKα1、BRSK1、MARK3、MARK4和NUAK1））的泛素链可能会激活或失活这些蛋白，从而支持泛素在调节信号传导中的作用。
观察到多个条带
Immunogen
对应于人线性泛素的卵清蛋白偶联的线性肽。
Other Notes
浓度：请参考特定批次的数据表。
Physical form
形式：纯化
纯化的小鼠单克隆IgG2bκ，溶于含0.1 M Tris-甘氨酸（pH 7.4）、150 mM NaCl和0.05％叠氮化钠的缓冲液中。
纯化蛋白G
Preparation Note
自接收之日起，在2-8°C下可稳定保存1年。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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