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Merck
CN

MABS487

Sigma-Aldrich

抗-修饰瓜氨酸抗体，克隆C4

clone C4, from human(Recombinant)

别名:

citrulline, modified citrulline

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关于此项目

UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41

主要文件

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生物来源

human (Recombinant)

质量水平

100

抗体形式

purified immunoglobulin

抗体产品类型

primary antibodies

克隆

C4, monoclonal

种属反应性（根据同源性预测）

all

技术

ELISA: suitable
western blot: suitable

同位素/亚型

IgG1λ

运输

wet ice

靶向翻译后修饰

unmodified

相关类别

一般描述

瓜氨酸被认为是一种未结合的氨基酸，在中间代谢中起作用。它是由肠上皮细胞在小肠中产生的。血浆和血清中的瓜氨酸浓度被认为是疾病期间小肠功能和小肠质量可靠且无创的生物标志物。瓜氨酸也被证明在蛋白质稳态中起着重要作用。改性瓜氨酸是瓜氨酸的化学改性形式，具有更高的免疫原性。

免疫原

经2,3-丁二酮单肟和安替比林修饰的含瓜氨酸的肽。

应用

研究子类别
信号神经科学
研究类别
信号传导
蛋白质印迹分析：一个代表性批次以1:1,000稀释度使用抗人二抗在10 µg处理的HL-60细胞裂解物中检测到修饰的瓜氨酸。
ELISA分析：一个代表性批次在ELISA中检测到了修饰的瓜氨酸。
这种抗修饰瓜氨酸抗体经验证可用于蛋白质印迹法和ELISA检测修饰瓜氨酸。

外形

人重组单克隆IgG1λ，溶于含0.05%叠氮化钠PBS的缓冲液中。
形式：纯化
纯化蛋白A

制备说明

自接收之日起，在2-8°C下可稳定保存1年。

分析说明

通过蛋白质印迹法在处理的角质化人细胞裂解物中进行评价。

蛋白质印迹分析：该抗体以1:1,000稀释度使用抗人二抗在10 µg处理的人角质化细胞裂解物中检测到修饰的瓜氨酸。

其他说明

浓度：请参考特定批次的数据表。

免责声明

除非我们的目录或产品随附的其他公司文件中另有说明，否则我们的产品预期仅用于研究用途，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或对人类或动物的任何类型的消费或应用。

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储存分类代码

10 - Combustible liquids

WGK

WGK 2

分析证书(COA)

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Issa O Yusuf et al.
Neurobiology of disease, 192, 106414-106414 (2024-01-23)
Alteration in protein citrullination (PC), a common posttranslational modification (PTM), contributes to pathogenesis in various inflammatory disorders. We previously reported that PC and protein arginine deiminase 2 (PAD2), the predominant enzyme isoform that catalyzes this PTM in the central nervous
Association of citrullination with the progression of aortic stenosis.
Kim, et al.
Scientific Reports, 13, 8919-8919 (2023)
Katerina D Samara et al.
Respiratory research, 18(1), 218-218 (2017-12-31)
Increased protein citrullination and peptidylarginine deiminases (PADIs), which catalyze the citrullination process, are central in Rheumatoid arthritis pathogenesis and probably involved in the initial steps towards autoimmunity. Approximately, 10% of RA patients develop clinically significantly ILD. A possible shared role
Seema Qamar et al.
Cell, 173(3), 720-734 (2018-04-21)
Reversible phase separation underpins the role of FUS in ribonucleoprotein granules and other membrane-free organelles and is, in part, driven by the intrinsically disordered low-complexity (LC) domain of FUS. Here, we report that cooperative cation-π interactions between tyrosines in the
Melissa M Ledet et al.
BMC cancer, 18(1), 412-412 (2018-04-14)
Mammary cancer is highly prevalent in dogs and cats and results in a poor prognosis due to critically lacking viable treatment options. Recent human and mouse studies have suggested that inhibiting peptidyl arginine deiminase enzymes (PAD) may be a novel
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