MABS82
抗磷酸-p70 S6激酶（Thr389）抗体，克隆10G7.1
clone 10G7.1, from mouse
别名:
Ribosomal protein S6 kinase beta-1, S6K-beta-1, S6K1, 70 kDa ribosomal protein S6 kinase 1, Short name=P70S6K1, p70-S6K 1, Ribosomal protein S6 kinase I, Serine/threonine-protein kinase 14A, p70 ribosomal S6 kinase alpha, p70 S6 kinase alpha, p70 S6K-alp
产品名称
抗磷酸-p70 S6激酶（Thr389）抗体，克隆10G7.1, clone 10G7.1, from mouse
biological source
mouse
antibody form
purified antibody
antibody product type
primary antibodies
clone
10G7.1, monoclonal
species reactivity
human, mouse
technique(s)
immunocytochemistry: suitable
western blot: suitable
isotype
IgG2aκ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
phosphorylation (pThr389)
Quality Level
Gene Information
human ... RPS6KB1(6198)
Analysis Note
对照
未处理和经血清处理的NIH/3T3细胞裂解液
未处理和经血清处理的NIH/3T3细胞裂解液
通过蛋白质印迹法在未处理和经血清处理的NIH/3T3细胞裂解液中进行了评估。
蛋白质印迹分析：1 µg/mL该抗体在10 µg未处理和经血清处理的NIH/3T3细胞裂解液中检测到p70 S6激酶。
蛋白质印迹分析：1 µg/mL该抗体在10 µg未处理和经血清处理的NIH/3T3细胞裂解液中检测到p70 S6激酶。
Application
免疫细胞化学分析：代表性批次的1:500稀释液在A431细胞中检测到p70 S6激酶。
抗磷酸-p70 S6激酶（Thr389）抗体，克隆10G7.1经验证可用于蛋白质印迹、ICC中抗磷酸-p70 S6激酶（Thr389）的检测。
研究子类别
细胞周期，DNA 复制&修复
细胞周期，DNA 复制&修复
研究类别
信号传导
信号传导
Biochem/physiol Actions
该抗体可识别在位点（Thr389）磷酸化的p70 S6激酶。 该抗体也可识别α 1和α 2亚型。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
p70s6激酶是一种普遍存在的细胞质蛋白，在细胞因子和生长因子（包括表皮生长因子和成纤维细胞生长因子）的反应中被激活。它位于mTOR/PI3K通路的下游，在多个残基上被磷酸化：Thr389、Thr229、Thr421、Ser371、Ser404、Ser411、Ser418和Ser424。Thr389、Ser371和Ser404位于连接子结构域；而Thr421、Ser411、Ser418、Ser424位于自抑制结构域，Thr229位于催化结构域。这些位点可能按等级顺序被磷酸化，导致p70s6激酶的激活。p70 S6激酶磷酸化40S核糖体蛋白（rpS6）上的S6蛋白，参与5’端寡聚嘧啶束mRNA分子调控、蛋白合成、细胞生长、增殖和细胞存活等多个过程。这种激酶的活性可能在糖尿病、癌症和衰老中起重要作用。
观测分子量~70/85 kDa。 该蛋白可识别α 1和α 2亚型。 在某些裂解物中，根据不同的处理条件，未表征的条带出现在〜18和〜200 kDa处。
Immunogen
与小鼠p70 S6激酶对应的KLH偶联线性肽在位点（Thr389）磷酸化。
表位：磷酸化（Thr389）
Other Notes
替代：04-392
浓度：请参考批次特异性浓缩物的检验报告。
Physical form
形式：纯化
纯化的小鼠单克隆IgG2aκ，溶于含有0.1 M Tris-甘氨酸（pH 7.4，150 mM NaCl）和0.05％叠氮化钠的缓冲液中。
蛋白G纯化
Preparation Note
自收到之日起，在2-8°C条件下可稳定保存1年。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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