MABT372
抗-Mastl抗体（克隆 4F9）
clone 4F9, from mouse
别名:
Serine/threonine-protein kinase greatwall, GW, GWL, hGWL, Microtubule-associated serine/threonine-protein kinase-like, MAST-L
产品名称
抗-Mastl抗体（克隆 4F9）, clone 4F9, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
4F9, monoclonal
species reactivity
human
technique(s)
immunohistochemistry: suitable
western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... MASTL(84930)
Application
使用经验证可用于蛋白质印迹和&IHC的该小鼠单克隆抗-Mastl 1抗体（克隆4F9）检测Mastl 。
免疫组化分析：一个代表性批次的 1：50-2,000 稀释液在人前列腺癌和人睾丸组织切片中检测到Mastl 。
研究子类别
粘附（CAMs）
粘附（CAMs）
研究类别
细胞结构
细胞结构
Analysis Note
通过蛋白质印迹对人口腔鳞状细胞癌裂解物进行了评估。
蛋白质印迹分析：1.0 µg/mL该抗体在10 µg 人口腔鳞状细胞癌裂解物中检测到Mastl。
蛋白质印迹分析：1.0 µg/mL该抗体在10 µg 人口腔鳞状细胞癌裂解物中检测到Mastl。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
Mastl也称丝氨酸/苏氨酸-蛋白激酶长城（GW）和微管相关丝氨酸/苏氨酸-蛋白激酶（MAST-L）。 Mastl 是一种丝氨酸/苏氨酸激酶，通过蛋白磷酸酶2A（PP2A）的失活，调节M 期有丝分裂的进入和维持。Mastl 也被认为参与巨核细胞分化和血小板减少症2（THC2）的调节。
观测值〜97 kDa。某些裂解液可能会出现未表征的条带。
Immunogen
对应于人Mastl的C末端的重组蛋白。
表位：C端
Other Notes
浓度：请参考批次特异性浓缩物的检验报告。
Physical form
形式：纯化
纯化的小鼠单克隆IgG1κ，溶于含0.1 M Tris-甘氨酸（pH 7.4），150 mM NaCl和0.05％叠氮化钠的缓冲液中。
蛋白G纯化
Preparation Note
自收到之日起，在2-8°C条件下可稳定保存1年。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Odjo G Gouttia et al.
Frontiers in cell and developmental biology, 10, 904719-904719 (2022-10-18)
Platinum-based chemotherapy is the standard first-line treatment for oral squamous cell carcinoma (OSCC) that is inoperable, recurrent, or metastatic. Platinum sensitivity is a major determinant of patient survival in advanced OSCC. Here, we investigated the involvement of MASTL, a cell
Srijayaprakash Babu Uppada et al.
Molecular cancer, 17(1), 111-111 (2018-08-03)
Chemotherapeutic agents that modulate cell cycle checkpoints and/or tumor-specific pathways have shown immense promise in preclinical and clinical studies aimed at anti-cancer therapy. MASTL (Greatwall in Xenopus and Drosophila), a serine/threonine kinase controls the final G2/M checkpoint and prevents premature
Dapeng Ren et al.
The Journal of biological chemistry, 292(24), 10026-10034 (2017-04-28)
Greatwall (Gwl) kinase plays an essential role in the regulation of mitotic entry and progression. Mitotic activation of Gwl requires both cyclin-dependent kinase 1 (CDK1)-dependent phosphorylation and its autophosphorylation at an evolutionarily conserved serine residue near the carboxyl terminus (Ser-883
Dario Hermida et al.
Molecular & cellular proteomics : MCP, 19(2), 326-343 (2019-12-20)
The human MASTL (Microtubule-associated serine/threonine kinase-like) gene encodes an essential protein in the cell cycle. MASTL is a key factor preventing early dephosphorylation of M-phase targets of Cdk1/CycB. Little is known about the mechanism of MASTL activation and regulation. MASTL
Yanqiu Li et al.
eLife, 12 (2023-09-06)
Checkpoint activation after DNA damage causes a transient cell cycle arrest by suppressing cyclin-dependent kinases (CDKs). However, it remains largely elusive how cell cycle recovery is initiated after DNA damage. In this study, we discovered the upregulated protein level of
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