产品名称
Anti-human IgM (10mg) KC, from mouse
isotype
IgG1
technique(s)
immunodiffusion: suitable
ELISA: suitable
biological source
mouse
antibody form
purified antibody
antibody product type
secondary antibodies
clone
monoclonal
species reactivity
human
Physical form
Purified mouse monoclonal in buffer containing 50 mM NaCl, 10 mM PBS, pH 8.0, 0.1 % sodium azide (NaN₃).
Format: Purified
Ion-exchange chromatography
Preparation Note
2-8°C. For long-term storage, freeze at -20°C.
Analysis Note
Tested
Application
Detect Human Serum IgM using this mouse monoclonal, Cat. No. MABX1911-10KC, validated for use in and ELISA and Lateral Flow Assay.
None
Research Category
Secondary & Control Antibodies
Secondary & Control Antibodies
Biochem/physiol Actions
Immunoglobulin M (IgM) plays a key role in engulfing the apoptotic cells. The reduction in serum IgM levels leads to increased autoimmune response and a higher risk of infections. IgM exhibits polyreactive and autoreactive functionality. A defect in IgM production is observed in X-linked agammaglobulinemia.
Specific for Human IgM. No cross reactivity with human IgA, IgD, IgE or IgG.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Secondary antibody specific for Human Immunoglobulin M
Immunoglobulin M (IgM) is a highly conserved antibody in vertebrates and is expressed early during development of immune system. It is present as a pentamer in the serum and is secreted by peritoneal B cells.
Immunoglobulin M (IgM) is a highly conserved antibody in vertebrates and is expressed early during development of immune system. It is present as a pentamer in the serum and is secreted by peritoneal B cells.
Immunogen
corresponding to Human Human Serum IgM.
Other Notes
Concentration: Please refer to lot specific datasheet.
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The importance of natural IgM: scavenger, protector and regulator
Ehrenstein MR and Notley CA
Nature Reviews: Immunology, 10(11), 778-786 (2010)
Protective roles of natural IgM antibodies
Gronwall C, et al.
Frontiers in immunology, 3, 66-66 (2012)
Structure and function of immunoglobulins.
Schroeder Jr HW and Cavacini L
The Journal of Allergy and Clinical Immunology, 125(2), S41-S52 (2010)
Caroline Grönwall et al.
Frontiers in immunology, 3, 66-66 (2012-05-09)
Antibodies are a vital part of the armamentarium of the adaptive immune system for the fine-tuning of the recognition and response to foreign threats. However, in health there are some types of antibodies that instead recognize self-antigens and these contribute
Harry W Schroeder et al.
The Journal of allergy and clinical immunology, 125(2 Suppl 2), S41-S52 (2010-03-05)
Immunoglobulins are heterodimeric proteins composed of 2 heavy and 2 light chains. They can be separated functionally into variable domains that bind antigens and constant domains that specify effector functions, such as activation of complement or binding to Fc receptors.
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