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MABX1911

Sigma-Aldrich

Anti-human IgM (10mg) KC

from mouse

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UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物来源

mouse

抗体形式

purified antibody

抗体产品类型

secondary antibodies

克隆

monoclonal

种属反应性

human

技术

ELISA: suitable
immunodiffusion: suitable

同位素/亚型

IgG1

相关类别

一般描述

Secondary antibody specific for Human Immunoglobulin M
Immunoglobulin M (IgM) is a highly conserved antibody in vertebrates and is expressed early during development of immune system. It is present as a pentamer in the serum and is secreted by peritoneal B cells.

特异性

Specific for Human IgM. No cross reactivity with human IgA, IgD, IgE or IgG.

免疫原

corresponding to Human Human Serum IgM.

应用

Detect Human Serum IgM using this mouse monoclonal, Cat. No. MABX1911-10KC, validated for use in and ELISA and Lateral Flow Assay.
None
Research Category
Secondary & Control Antibodies

生化/生理作用

Immunoglobulin M (IgM) plays a key role in engulfing the apoptotic cells. The reduction in serum IgM levels leads to increased autoimmune response and a higher risk of infections. IgM exhibits polyreactive and autoreactive functionality. A defect in IgM production is observed in X-linked agammaglobulinemia.

质量

Tested

外形

Ion-exchange chromatography
Format: Purified
Purified mouse monoclonal in buffer containing 50 mM NaCl, 10 mM PBS, pH 8.0, 0.1 % sodium azide (NaN₃).

储存及稳定性

2-8°C. For long-term storage, freeze at -20°C.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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The importance of natural IgM: scavenger, protector and regulator
Ehrenstein MR and Notley CA
Nature Reviews: Immunology, 10(11), 778-786 (2010)
Protective roles of natural IgM antibodies
Gronwall C, et al.
Frontiers in immunology, 3, 66-66 (2012)
Structure and function of immunoglobulins.
Schroeder Jr HW and Cavacini L
The Journal of Allergy and Clinical Immunology, 125(2), S41-S52 (2010)
Caroline Grönwall et al.
Frontiers in immunology, 3, 66-66 (2012-05-09)
Antibodies are a vital part of the armamentarium of the adaptive immune system for the fine-tuning of the recognition and response to foreign threats. However, in health there are some types of antibodies that instead recognize self-antigens and these contribute
Harry W Schroeder et al.
The Journal of allergy and clinical immunology, 125(2 Suppl 2), S41-S52 (2010-03-05)
Immunoglobulins are heterodimeric proteins composed of 2 heavy and 2 light chains. They can be separated functionally into variable domains that bind antigens and constant domains that specify effector functions, such as activation of complement or binding to Fc receptors.

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