00920
N-乙酰基-L-天冬氨酸
≥99.0% (T)
别名:
(2S)-2-Acetamidobutanedioic acid, N-Acetyl-S-aspartic acid
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关于此项目
线性分子式:
HO2CCH2CH(NHCOCH3)CO2H
化学文摘社编号:
分子量:
175.14
NACRES:
NA.22
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352209
MDL number:
Beilstein/REAXYS Number:
1726198
产品名称
N-乙酰基-L-天冬氨酸, ≥99.0% (T)
InChI
1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/t4-/m0/s1
SMILES string
CC(=O)N[C@@H](CC(O)=O)C(O)=O
InChI key
OTCCIMWXFLJLIA-BYPYZUCNSA-N
assay
≥99.0% (T)
form
powder
optical activity
[α]20/D +12±1°, c = 2% in 6 M HCl
reaction suitability
reaction type: solution phase peptide synthesis
color
colorless to white
mp
137-140 °C (lit.)
141-146 °C
application(s)
peptide synthesis
Quality Level
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Other Notes
综述；大脑中乙酰胆碱合成时的乙酰基供体。
Application
N-乙酰基-L-天门冬氨酸可用作合成以下物质的反应物：
- 通过选择性还原和酸催化环化反应形成受保护的高丝氨酸γ-内酯。
- 通过环缩合形成外消旋氨基取代琥珀酰亚胺衍生物。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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The early time course after acute stroke of cerebral N-acetylaspartate, creatine and phosphocreatine, and compounds containing choline was studied in vivo by means of localized water-suppressed proton magnetic resonance spectroscopy. Eight patients with acute stroke were studied serially in the
Maria A Rocca et al.
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Previous work has suggested that functional reorganization of cortical areas might have a role in limiting the clinical impact of axonal pathology in patients with established multiple sclerosis (MS). Since there is evidence for irreversible tissue damage even in patients
Paola Leone et al.
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Canavan disease is a hereditary leukodystrophy caused by mutations in the aspartoacylase gene (ASPA), leading to loss of enzyme activity and increased concentrations of the substrate N-acetyl-aspartate (NAA) in the brain. Accumulation of NAA results in spongiform degeneration of white
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