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Merck
CN

08984

丁酰基- L -肉碱

analytical standard

别名:

C4-肉碱, 丁酰基- L -肉碱, (2 R )-3-羧基- N N N -三甲基-2-(1-氧代丁氧基)-1-丙胺 内盐

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关于此项目

经验公式(希尔记法):
C11H21NO4
化学文摘社编号:
分子量:
231.29
UNSPSC Code:
41116107
NACRES:
NB.21
MDL number:
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grade

analytical standard

Quality Level

assay

≥97.0% (HPLC)

optical activity

[α]/D -23.0±2.0°, c = 0.1 in H2O

shelf life

limited shelf life, expiry date on the label

impurities

≤10.0% water

application(s)

clinical testing

format

neat

storage temp.

2-8°C

SMILES string

C[N+](C)(C)C[C@H](OC(CCC)=O)CC([O-])=O

InChI

1S/C11H21NO4/c1-5-6-11(15)16-9(7-10(13)14)8-12(2,3)4/h9H,5-8H2,1-4H3/t9-/m1/s1

InChI key

QWYFHHGCZUCMBN-SECBINFHSA-N

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General description

Butyryl-L-carnitine is a naturally occurring compound belonging to the acylcarnitine class of compounds as listed in the human metabolome database (HMBD). These compounds are reported to be used as biomarkers in the diagnosis of carnitine deficiency. It acts as a carrier of long chain acyl groups from activated fatty acids across the inner mitochondrial membrane into the mitochondrial matrix where they undergo β-oxidation to acetyl CoA to obtain usable energy via the citric acid cycle.

Application

Butyryl-L-carnitine may be used as an analytical reference standard for the separation and identification of underivatized butyryl-L-carnitine in human plasma samples using high-performance liquid chromatography coupled to tandem mass spectrometry (HPLC-MS/MS). It may also be used as an analytical reference standard for the quantification of the analyte in biological samples using chromatography-based techniques.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Tracing and separating plasma components causing matrix effects in hydrophilic interaction chromatography?electrospray ionization mass spectrometry
Journal of Chromatography. B, Biomedical Sciences and Applications, 923, 83-91 (2013)
Metabolomic analyses reveal extensive progenitor cell deficiencies in a mouse model of duchenne muscular dystrophy
Joseph J, et al.
Metabolites, 8(4), 61-61 (2018)
Separation and identification of underivatized plasma acylcarnitine isomers using liquid chromatography?tandem mass spectrometry for the differential diagnosis of organic acidemias and fatty acid oxidation defects
Peng M, et al.
Journal of Chromatography A, 1319, 97-106 (2016)
Exogenous carnitine application augments transport of fatty acids into mitochondria and stimulates mitochondrial respiration in maize seedlings grown under normal and cold conditions
Turk H, et al.
Cryobiology, 9, 97-103 (2019)
Ralph Fingerhut et al.
Analytical chemistry, 81(9), 3571-3575 (2009-03-28)
Electrospray ionization-tandem mass spectrometry (ESI-MS/MS) is increasingly used in newborn screening programs. Acylcarnitine profiles from dried blood spots (DBS) are used to detect fatty acid oxidation disorders, carnitine cycle disorders, and organic acidurias. Stored dried blood is also a valuable

全球贸易项目编号

货号GTIN
70090-100ML04061832795935
W244503-4KG-K04061837544934
W244503-SAMPLE-K04061837512766
W244503-9KG-K04061837544941
W244511-1KG-K04061834365471
W244511-500G-K04061834404156
W244511-SAMPLE-K04061834355212
04597-1ML04061838633781
W244503-20KG-K04061837544927
W244503-1KG-K04061837544910

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