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经验公式(希尔记法):
C27H31N2NaO6S2
化学文摘社编号:
分子量:
566.66
PubChem Substance ID:
UNSPSC Code:
12171500
Colour Index Number:
42045
NACRES:
NA.47
EC Number:
204-934-1
MDL number:
产品名称
专利蓝 VF, Dye content 50 %
InChI key
SJEYSFABYSGQBG-UHFFFAOYSA-M
InChI
1S/C27H32N2O6S2.Na/c1-5-28(6-2)22-13-9-20(10-14-22)27(21-11-15-23(16-12-21)29(7-3)8-4)25-18-17-24(36(30,31)32)19-26(25)37(33,34)35;/h9-19H,5-8H2,1-4H3,(H-,30,31,32,33,34,35);/q;+1/p-1
SMILES string
[Na+].CCN(CC)c1ccc(cc1)\C(=C2/C=CC(\C=C2)=[N+](\CC)CC)c3ccc(cc3S([O-])(=O)=O)S([O-])(=O)=O
form
powder
composition
Dye content, 50%
technique(s)
microbe id | staining: suitable
solubility
H2O: 1 mg/mL
λmax
635 nm (2nd)
-410 nm
ε (extinction coefficient)
≥50000 at 635-641 nm in H2O
≥5300 at 408-414 nm in H2O
≥7500 at 308-314 nm in H2O
application(s)
diagnostic assay manufacturing
hematology
histology
storage temp.
room temp
Quality Level
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Application
使用了专利蓝 VF:
- 联合 99mTc 植酸钠检测早期宫颈癌患者前哨淋巴结 (SLN)。
- 检测热休克蛋白 (HSP) gp96 诱导的小鼠引流淋巴结 (LN)。
- 检测 Asn-Gly-Arg (NGR)-肿瘤坏死因子 (TNF) 对小鼠模型肿瘤灌注的影响。
Biochem/physiol Actions
专利蓝 VF 染料是紫色粉末。已用于化妆品着色。
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Blue dyes in medicine--a confusing terminology.
Kathrin Scherer et al.
Contact dermatitis, 54(4), 231-232 (2006-05-03)
Sentinel lymph node detection in early cervical cancer with combination 99mTc phytate and patent blue.
Niikura H
Gynecologic Oncology, 94(2), 528-532 (2004)
Synergistic antitumor activity of cisplatin, paclitaxel, and gemcitabine with tumor vasculature-targeted tumor necrosis factor-alpha.
Sacchi A
Clinical Cancer Research, 12(1), 175-182 (2006)
Cutting Edge: Heat Shock Protein gp96
Induces Maturation and Migration of
CD11c1 Cells In Vivo
Induces Maturation and Migration of
CD11c1 Cells In Vivo
Binder R J
Journal of Immunology, 165, 6029-6035 (2000)
Benoit Ayestaray et al.
Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 66(3), 382-389 (2012-12-12)
Lymphoedema supermicrosurgery is known to be difficult to perform. Lymphatic vessels are not easy to individualise, because of their small calibre (inferior to 1 mm) and their translucent appearance. Patent blue is an organic colourant, which is able to enhance
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