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形式
powder
质量水平
组成
Dye content, 60%
λmax
407 nm (2nd)
570 nm
应用
diagnostic assay manufacturing
hematology
histology
储存温度
room temp
SMILES字符串
[Na+].[Na+].[Na+].[Na+].CC(=O)Nc1ccc(c2cc(c(\N=N\c3ccc(\N=N/c4ccc(cc4)S([O-])(=O)=O)c5ccc(cc35)S([O-])(=O)=O)c(O)c12)S([O-])(=O)=O)S([O-])(=O)=O
InChI
1S/C28H21N5O14S4.4Na/c1-14(34)29-23-10-11-24(50(42,43)44)20-13-25(51(45,46)47)27(28(35)26(20)23)33-32-22-9-8-21(18-7-6-17(12-19(18)22)49(39,40)41)31-30-15-2-4-16(5-3-15)48(36,37)38;;;;/h2-13,35H,1H3,(H,29,34)(H,36,37,38)(H,39,40,41)(H,42,43,44)(H,45,46,47);;;;/q;4*+1/p-4/b31-30-,33-32+;;;;
InChI key
GMMAPXRGRVJYJY-OXYXOBGMSA-J
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应用
Brilliant Black BN has been used:
- in micronucleus and comet assays to evaluate its genotoxic effect.
- as a quenching agent in calcium mobilization assay.
- as a redox indicator in microbiological inhibition bioassay using Bacillus megaterium to detect tetracycline and macrolides in milk.
生化/生理作用
[4-acetamido-5-hydroxy-6-[7-sulfonato-4-(4-sulfonatophenylazo)-1-naphtylazo], also known as food black 1, belongs to the group of azo dyes. Brilliant Black BN is widely used as a food dye and pharmaceutical excipient. In addition, it also acts as an allosteric modulator of the adenosine A1 and A3 receptors and is generally used within calcium mobilization assays to reduce extracellular fluorescence.
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Antagonist selective modulation of adenosine A1 and A3 receptor pharmacology by the food dye Brilliant Black BN: evidence for allosteric interactions.
May LT
Molecular Pharmacology, 77, 678-686 (2010)
Microbiological Method using Bacillus megaterium
with Fusidic Acid for Detection of Macrolides in Milk
with Fusidic Acid for Detection of Macrolides in Milk
Tumin M
Czech Journal of Food Sciences, 34, 9-15 (2016)
Calcium Mobilisation Assay in Response to Chemokine Stimulation
Cronshaw DG
Bio-protocol, 2 (2012)
The evaluation of the genotoxicity of two commonly used food colors: Quinoline Yellow (E 104) and Brilliant Black BN (E 151).
Cellular & Molecular Biology Letters, 9, 107-122 (2004)
Andrew Joiner et al.
Journal of dentistry, 36 Suppl 1, S8-14 (2008-07-23)
To investigate a new optical approach to tooth whitening by enhancing the measurement and perception of tooth whiteness using blue coloured materials deposited onto the tooth surface. Salivary pellicle coated human extracted teeth or polished enamel specimens were used as
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