390062
噻唑橙
Dye content ~90 %
别名:
1-甲基-4-[(3-甲基-2(3H)-苯并噻唑基)甲基]喹啉 对甲苯磺酸
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关于此项目
经验公式(希尔记法):
C26H24N2O3S2
化学文摘社编号:
分子量:
476.61
MDL编号:
UNSPSC代码:
12171500
PubChem化学物质编号:
NACRES:
NA.47
表单
powder
质量水平
组成
Dye content, ~90%
技术
titration: suitable
mp
270 °C (dec.) (lit.)
λmax
512 nm
应用
diagnostic assay manufacturing
hematology
histology
储存温度
room temp
SMILES字符串
Cc1ccc(cc1)S([O-])(=O)=O.CN2C(\Sc3ccccc23)=C\c4cc[n+](C)c5ccccc45
InChI
1S/C19H17N2S.C7H8O3S/c1-20-12-11-14(15-7-3-4-8-16(15)20)13-19-21(2)17-9-5-6-10-18(17)22-19;1-6-2-4-7(5-3-6)11(8,9)10/h3-13H,1-2H3;2-5H,1H3,(H,8,9,10)/q+1;/p-1
InChI key
ACOJCCLIDPZYJC-UHFFFAOYSA-M
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一般描述
噻唑橙可与肽核酸连接,用于检测均质溶液中的目标核酸。它是一种染料并且具有良好网织红细胞染料的预测物理特性和生物染色特征,因此,它被作为一种用于网织红细胞分析的染料。它在与核酸结合后,特别是RNA,产生大幅的荧光增强和高量子产率。它不会发生沉淀,并且可以透过活细胞膜。
应用
噻唑橙已可用于染色并定量网织红细胞。
警示用语:
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Phong Lan Thao Tran et al.
Biochimie, 93(8), 1288-1296 (2011-06-07)
The potential formation of G-quadruplexes in many regions of the genome makes them an attractive target for drug design. A large number of small molecules synthesized in recent years display an ability to selectively target and stabilize G-quadruplexes. To screen for
Adam D Cawte et al.
Nature communications, 11(1), 1283-1283 (2020-03-11)
RNA molecules play vital roles in many cellular processes. Visualising their dynamics in live cells at single-molecule resolution is essential to elucidate their role in RNA metabolism. RNA aptamers, such as Spinach and Mango, have recently emerged as a powerful
Danitza Nébor et al.
Scientific reports, 8(1), 12793-12793 (2018-08-26)
Anemic Nan mice carry a mutation (E339D) in the second zinc finger of erythroid transcription factor KLF1. Nan-KLF1 fails to bind a subset of normal KLF1 targets and ectopically binds a large set of genes not normally engaged by KLF1
Light-up probes: thiazole orange-conjugated peptide nucleic acid for detection of target nucleic acid in homogeneous solution.
Svanvik N
Analytical Biochemistry, 281(1), 26-35 (2000)
Eeman Khorramian et al.
Shock (Augusta, Ga.), 48(4), 490-497 (2017-04-30)
Intensive care unit (ICU) anemia is an extreme version of anemia of inflammation that occurs commonly in critically ill patients and is associated with increased morbidity and mortality. Currently available therapies for ICU anemia have shown inconsistent efficacies in clinical
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