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Merck
CN

390062

噻唑橙

Dye content ~90 %

别名:

1-甲基-4-[(3-甲基-2(3H)-苯并噻唑基)甲基]喹啉 甲苯磺酸

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关于此项目

经验公式(希尔记法):
C26H24N2O3S2
化学文摘社编号:
分子量:
476.61
NACRES:
NA.47
PubChem Substance ID:
UNSPSC Code:
12171500
MDL number:
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InChI

1S/C19H17N2S.C7H8O3S/c1-20-12-11-14(15-7-3-4-8-16(15)20)13-19-21(2)17-9-5-6-10-18(17)22-19;1-6-2-4-7(5-3-6)11(8,9)10/h3-13H,1-2H3;2-5H,1H3,(H,8,9,10)/q+1;/p-1

SMILES string

Cc1ccc(cc1)S([O-])(=O)=O.CN2C(\Sc3ccccc23)=C\c4cc[n+](C)c5ccccc45

InChI key

ACOJCCLIDPZYJC-UHFFFAOYSA-M

form

powder

composition

Dye content, ~90%

technique(s)

titration: suitable

mp

270 °C (dec.) (lit.)

λmax

512 nm

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

Quality Level

General description

噻唑橙可与肽核酸连接,用于检测均质溶液中的目标核酸。它是一种染料并且具有良好网织红细胞染料的预测物理特性和生物染色特征,因此,它被作为一种用于网织红细胞分析的染料。它在与核酸结合后,特别是RNA,产生大幅的荧光增强和高量子产率。它不会发生沉淀,并且可以透过活细胞膜。

Application

噻唑橙已可用于染色并定量网织红细胞。

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Danitza Nébor et al.
Scientific reports, 8(1), 12793-12793 (2018-08-26)
Anemic Nan mice carry a mutation (E339D) in the second zinc finger of erythroid transcription factor KLF1. Nan-KLF1 fails to bind a subset of normal KLF1 targets and ectopically binds a large set of genes not normally engaged by KLF1
Adam D Cawte et al.
Nature communications, 11(1), 1283-1283 (2020-03-11)
RNA molecules play vital roles in many cellular processes. Visualising their dynamics in live cells at single-molecule resolution is essential to elucidate their role in RNA metabolism. RNA aptamers, such as Spinach and Mango, have recently emerged as a powerful
Eeman Khorramian et al.
Shock (Augusta, Ga.), 48(4), 490-497 (2017-04-30)
Intensive care unit (ICU) anemia is an extreme version of anemia of inflammation that occurs commonly in critically ill patients and is associated with increased morbidity and mortality. Currently available therapies for ICU anemia have shown inconsistent efficacies in clinical
Costimulation blockade, busulfan, and bone marrow promote titratable macrochimerism, induce transplantation tolerance, and correct genetic hemoglobinopathies with minimal myelosuppression.
Adams AB
Journal of Immunology, 167(2), 1103-1111 (2001)
Light-up probes: thiazole orange-conjugated peptide nucleic acid for detection of target nucleic acid in homogeneous solution.
Svanvik N
Analytical Biochemistry, 281(1), 26-35 (2000)

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