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经验公式(希尔记法):
C26H24N2O3S2
化学文摘社编号:
分子量:
476.61
NACRES:
NA.47
PubChem Substance ID:
UNSPSC Code:
12171500
MDL number:
InChI
1S/C19H17N2S.C7H8O3S/c1-20-12-11-14(15-7-3-4-8-16(15)20)13-19-21(2)17-9-5-6-10-18(17)22-19;1-6-2-4-7(5-3-6)11(8,9)10/h3-13H,1-2H3;2-5H,1H3,(H,8,9,10)/q+1;/p-1
SMILES string
Cc1ccc(cc1)S([O-])(=O)=O.CN2C(\Sc3ccccc23)=C\c4cc[n+](C)c5ccccc45
InChI key
ACOJCCLIDPZYJC-UHFFFAOYSA-M
form
powder
composition
Dye content, ~90%
technique(s)
titration: suitable
mp
270 °C (dec.) (lit.)
λmax
512 nm
application(s)
diagnostic assay manufacturing
hematology
histology
storage temp.
room temp
Quality Level
General description
噻唑橙可与肽核酸连接,用于检测均质溶液中的目标核酸。它是一种染料并且具有良好网织红细胞染料的预测物理特性和生物染色特征,因此,它被作为一种用于网织红细胞分析的染料。它在与核酸结合后,特别是RNA,产生大幅的荧光增强和高量子产率。它不会发生沉淀,并且可以透过活细胞膜。
Application
噻唑橙已可用于染色并定量网织红细胞。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Danitza Nébor et al.
Scientific reports, 8(1), 12793-12793 (2018-08-26)
Anemic Nan mice carry a mutation (E339D) in the second zinc finger of erythroid transcription factor KLF1. Nan-KLF1 fails to bind a subset of normal KLF1 targets and ectopically binds a large set of genes not normally engaged by KLF1
Adam D Cawte et al.
Nature communications, 11(1), 1283-1283 (2020-03-11)
RNA molecules play vital roles in many cellular processes. Visualising their dynamics in live cells at single-molecule resolution is essential to elucidate their role in RNA metabolism. RNA aptamers, such as Spinach and Mango, have recently emerged as a powerful
Eeman Khorramian et al.
Shock (Augusta, Ga.), 48(4), 490-497 (2017-04-30)
Intensive care unit (ICU) anemia is an extreme version of anemia of inflammation that occurs commonly in critically ill patients and is associated with increased morbidity and mortality. Currently available therapies for ICU anemia have shown inconsistent efficacies in clinical
Costimulation blockade, busulfan, and bone marrow promote titratable macrochimerism, induce transplantation tolerance, and correct genetic hemoglobinopathies with minimal myelosuppression.
Adams AB
Journal of Immunology, 167(2), 1103-1111 (2001)
Light-up probes: thiazole orange-conjugated peptide nucleic acid for detection of target nucleic acid in homogeneous solution.
Svanvik N
Analytical Biochemistry, 281(1), 26-35 (2000)
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