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Merck
CN

63177

6-(马来酰亚胺基)己酸琥珀酰亚胺酯

≥98.0% (HPLC)

别名:

6-马来酰亚氨基己酸 N-琥珀酰亚胺酯, N-(ε-马来酰亚胺己酰氧)琥珀酰亚胺, N-琥珀酰亚胺 6-马来酰亚胺己酸酯, EMCS

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关于此项目

经验公式(希尔记法):
C14H16N2O6
化学文摘社编号:
分子量:
308.29
UNSPSC Code:
12352106
NACRES:
NA.25
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
1499815
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产品名称

6-(马来酰亚胺基)己酸琥珀酰亚胺酯, ≥98.0% (HPLC)

InChI key

VLARLSIGSPVYHX-UHFFFAOYSA-N

SMILES string

O=C(ON(C(CC1)=O)C1=O)CCCCCN2C(C=CC2=O)=O

InChI

1S/C14H16N2O6/c17-10-5-6-11(18)15(10)9-3-1-2-4-14(21)22-16-12(19)7-8-13(16)20/h5-6H,1-4,7-9H2

assay

≥98.0% (HPLC)

form

solid

reaction suitability

reagent type: linker

Quality Level

mp

70-73 °C (lit.)

functional group

NHS ester

storage temp.

−20°C

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Application

6-Maleimidohexanoic acid N-hydroxysuccinimide ester is a heterobifunctional cross-linking reagent with amine and sulfhydryl reactivity. Typically, coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). Second coupling specific for molecules containing free sulfhydryl by thioether linkage buffered at pH 6.8 (6.5-7.0). Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates.

Other Notes

Reagent for cross-linking and immobilisation of proteins

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

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历史批次信息供参考:

分析证书(COA)

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T. Kitagawa
Enzyme Immunoassay, 81-81 (1981)
Mitsuko Maeda et al.
Bioorganic & medicinal chemistry letters, 15(3), 621-624 (2005-01-25)
The adenovirus vector is a promising carrier for the efficient transfer of genes into cells via the coxackie-adenovirus receptor (CAR) and integrins (alphavbeta3 and alphavbeta5). The clinical use of the adenovirus vector remains problematic however. Successful administration of this vector
Preparation and characterization of hetero-bifunctional cross-linking reagents for protein modifications.
Kitagawa, T., et al.
Chemical & Pharmaceutical Bulletin, 29, 1130-1130 (1981)
N J Maeji et al.
Journal of immunological methods, 146(1), 83-90 (1992-01-21)
Recently, the multipin approach for simultaneous multiple peptide synthesis was applied to the analysis of T cell determinants by using a novel cleavage method (Maeji et al., 1990). A diketopiperazine forming linker allowed cleavage of peptides into aqueous buffer which
Y Nakano et al.
International archives of allergy and immunology, 120(3), 199-208 (1999-12-11)
We have previously reported that ovalbumin (OVA) coupled with liposome via glutaraldehyde (GA) induced OVA-specific- and IgE-selective unresponsiveness in mice. In this study, OVA-liposome conjugates were made using four different coupling protocols: via GA, N-(6-maleimidocaproyloxy) succinimide (EMCS), disuccinimidyl suberate (DSS)

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