75047
胡椒碱
analytical standard
别名:
1-胡椒酰哌啶
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关于此项目
经验公式（希尔记法）:
C17H19NO3
化学文摘社编号:
分子量:
285.34
UNSPSC Code:
85151701
NACRES:
NA.24
PubChem Substance ID:
EC Number:
202-348-0
Beilstein/REAXYS Number:
90741
MDL number:
产品名称
胡椒碱, analytical standard
InChI
1S/C17H19NO3/c19-17(18-10-4-1-5-11-18)7-3-2-6-14-8-9-15-16(12-14)21-13-20-15/h2-3,6-9,12H,1,4-5,10-11,13H2/b6-2+,7-3+
SMILES string
O=C(\C=C\C=C\c1ccc2OCOc2c1)N3CCCCC3
InChI key
MXXWOMGUGJBKIW-YPCIICBESA-N
grade
analytical standard
assay
≥97.0% (HPLC)
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
mp
131-135 °C (lit.)
application(s)
cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care
format
neat
storage temp.
2-8°C
Quality Level
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Application
Piperine may be used as an analytical reference standard for the quantification of the analyte in:
- Human plasma using high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS).
- Piper nigrum extract using reversed phase high pressure liquid chromatographic method with UV detection (RP-HPLC-UV).
- Food products using high-performance liquid chromatography with diode array detection (HPLC-DAD).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
General description
Piperine is a naturally occurring bioactive alkaloid in pepper, which imparts pungency and bitter flavor to it. It has demonstrated health benefits and exhibits therapeutic properties, which include its role as an antimicrobial, antioxidant, antifungal, immunomodulatory and hepatoprotective agent. The inhibition of drug-metabolizing enzymes in hepatic and pulmonary tissues, and the enhancement of drug bioavailability by this compound are reported. It is also found to play an important role in reducing blood glucose, cholesterol and triglycerides.
Piperine is an amide isolated from the plant, Piper longum. It is a known inhibitor of hepatic and intestinal glucuronidation. Piperine is found to exhibit pharmacological properties like antitumor, antipyretic and anti-inflammatory activities.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 2
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
此项目有
A liquid chromatography method for the simultaneous determination of curcumin and piperine in food products using diode array detection
Nagappan VK , et al.
Asian Journal of Research in Chemistry, 2(2), 115-118 (2009)
Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers
Shoba G, et al.
Planta Medica, 64(04), 353- 356 (1998)
Immunomodulatory and antitumor activity of Piper longum Linn. and piperine
Sunila.S.E and Kuttan.G
Journal of Ethnopharmacology, 90(2), 339- 346 (2004)
Piperine?the bioactive compound of black pepper: from isolation to medicinal formulations
Gorgani L, et al.
Comprehensive Reviews in Food Science and Food Safety, 16(1), 124-140 (2017)
Development and validation of rapid RP-HPLC method for estimation of piperine in Piper nigrum L
Upadhyay V, et al.
International Journal of Herbal Medicine, 1, 6-9 (2013)
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