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Merck
CN

901425

Sigma-Aldrich

White-Clark catalyst

powder

别名:

[MnIII(ClPc)]Cl

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关于此项目

经验公式(希尔记法):
C32Cl17MnN8
化学文摘社编号:
分子量:
1154.04
MDL编号:
UNSPSC代码:
12161600
NACRES:
NA.22
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应用

This catalyst is useful for late-stage functionalization of complex compounds through C-H amination. This catalyst is highly reactive and selective for amination at benzylic positions. The benzylic amination is highly selective over tertiary amination. In substrates with multiple benzylic sites, the preference is for amination at the least sterically encumbered and most electron rich site, irrespective of bond dissociation energy (BDE). Substrates containing basic nitrogen (tertiary amines, pyridine, benzimidazole) can be effectively protected for the first time using this catalyst with a Brønsted (HBF4) or Lewis acid (BF3), to give remotely aminated products. Late-stage amination has been demonstrated on a series of drugs and drug-like molecules, including citalopram, analogs of estrone and dextromethorphan, and biflavanoids, many of which cannot be accessed by other amination methods due to the presence of basic nitrogens.

法律信息

This product is patent pending under application #62/569,872.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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