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917397

(2-(Piperidin-4-yl)phenyl)methanamine dihydrochloride

Name: (2-(Piperidin-4-yl)phenyl)methanamine dihydrochloride
Brand: SIAL

别名:

Semi-flexible linker for PROTAC^® development

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关于此项目

经验公式（希尔记法）:

C₁₂H₂₀Cl₂N₂

化学文摘社编号:

2244085-89-8

分子量:

263.21

UNSPSC Code:

12352116

NACRES:

NA.22

MDL number:

MFCD29075589

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属性

form

powder

Quality Level

100

reaction suitability

reagent type: linker

functional group

amine

storage temp.

2-8°C

SMILES string

NCC1=C(C=CC=C1)C2CCNCC2.Cl.Cl

InChI

1S/C12H18N2.2ClH/c13-9-11-3-1-2-4-12(11)10-5-7-14-8-6-10;;/h1-4,10,14H,5-9,13H2;2*1H

InChI key

VBWHHONSCAVPOS-UHFFFAOYSA-N

说明

Application

(2-(Piperidin-4-yl)phenyl)methanamine dihydrochloride is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

Other Notes

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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全球贸易项目编号

货号	GTIN
917397-100MG	04061842601707