917397
(2-(Piperidin-4-yl)phenyl)methanamine dihydrochloride
别名:
Semi-flexible linker for PROTAC® development
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关于此项目
经验公式（希尔记法）:
C12H20Cl2N2
化学文摘社编号:
分子量:
263.21
UNSPSC Code:
12352116
NACRES:
NA.22
MDL number:
form
powder
Quality Segment
reaction suitability
reagent type: linker
technique(s)
targeted protein degradation: suitable
functional group
amine
storage temp.
2-8°C
SMILES string
NCC1=C(C=CC=C1)C2CCNCC2.Cl.Cl
InChI
1S/C12H18N2.2ClH/c13-9-11-3-1-2-4-12(11)10-5-7-14-8-6-10;;/h1-4,10,14H,5-9,13H2;2*1H
InChI key
VBWHHONSCAVPOS-UHFFFAOYSA-N
Application
(2-(Piperidin-4-yl)phenyl)methanamine dihydrochloride is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.
Other Notes
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
存储类别
11 - Combustible Solids
怎么回事？
WGK 3
闪点 (F)
Not applicable
闪点 (°C)
Not applicable