917400
tert-Butyl 4-(3-(hydroxymethyl)phenyl)piperidine-1-carboxylate
≥95%
别名:
Semi-flexible linker for PROTAC® development
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关于此项目
经验公式（希尔记法）:
C17H25NO3
化学文摘社编号:
分子量:
291.39
UNSPSC Code:
12352116
NACRES:
NA.22
MDL number:
产品名称
tert-Butyl 4-(3-(hydroxymethyl)phenyl)piperidine-1-carboxylate, ≥95%
InChI key
OWDXAWCQYCRTIR-UHFFFAOYSA-N
SMILES string
O=C(N(CC1)CCC1C2=CC(CO)=CC=C2)OC(C)(C)C
assay
≥95%
form
powder
reaction suitability
reagent type: linker
functional group
Boc
hydroxyl
storage temp.
2-8°C
Quality Level
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Application
tert-Butyl 4-(3-(hydroxymethyl)phenyl)piperidine-1-carboxylate is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.
Other Notes
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
signalword
Warning
hcodes
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
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Van T H Ngo et al.
Bioorganic & medicinal chemistry, 26(5), 1035-1049 (2018-02-06)
Pyroglutamate-modified amyloid β peptides (pGlu-Aβ) are highly neurotoxic and promote the formation of amyloid plaques. The pGlu-Aβ peptides are generated by glutaminyl cyclase (QC), and recent clinical studies indicate that QC represents an alternative therapeutic target to treat Alzheimer's disease
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