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Y0001378

柚皮苷

Name: 柚皮苷
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

别名:

4‘;5,7-三羟基黄酮 7-鼠李糖苷, 柚皮素 7-新橙皮苷, 柚皮素-7-鼠李糖苷, 柚皮苷

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关于此项目

经验公式（希尔记法）:

C₂₇H₃₂O₁₄

化学文摘社编号:

10236-47-2

分子量:

580.53

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329831392

MDL number:

MFCD00148888

Beilstein/REAXYS Number:

102012

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属性

grade

pharmaceutical primary standard

API family

naringin

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]2Oc3cc(O)c4C(=O)CC(Oc4c3)c5ccc(O)cc5)[C@H](O)[C@H](O)[C@H]1O

InChI

1S/C27H32O14/c1-10-20(32)22(34)24(36)26(37-10)41-25-23(35)21(33)18(9-28)40-27(25)38-13-6-14(30)19-15(31)8-16(39-17(19)7-13)11-2-4-12(29)5-3-11/h2-7,10,16,18,20-30,32-36H,8-9H2,1H3/t10-,16?,18+,20-,21+,22+,23-,24+,25+,26-,27+/m0/s1

InChI key

DFPMSGMNTNDNHN-JJLSSNRUSA-N

说明

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Naringin EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

柚皮苷是葡萄柚和其他柑橘类水果中的黄酮类化合物，可强效抑制肠道有机阴离子转运多肽 1A2 (OATP1A2)。因此，葡萄柚汁可降低同时服用的许多药物的生物利用度。

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Novel oxime based flavanone, naringin-oxime: synthesis, characterization and screening for antioxidant activity.

Mustafa Ozyürek et al.

Chemico-biological interactions, 212, 40-46 (2014-02-11)

Recent interest in polyphenolic antioxidants due to their involvement in health benefits has led to the investigation of new polyphenolic compounds with enhanced antioxidant activity. Naringin (4',5,7-trihydroxyflavanone-7-β-l-rhamnoglucoside-(1,2)-α-d-glucopyranoside) is one of the major flavanones in citrus and grapefruit. The present study

Naringin ameliorates gentamicin-induced nephrotoxicity and associated mitochondrial dysfunction, apoptosis and inflammation in rats: possible mechanism of nephroprotection.

Bidya Dhar Sahu et al.

Toxicology and applied pharmacology, 277(1), 8-20 (2014-03-19)

Gentamicin-induced nephrotoxicity has been well documented, although its underlying mechanisms and preventive strategies remain to be investigated. The present study was designed to investigate the protective effect of naringin, a bioflavonoid, on gentamicin-induced nephrotoxicity and to elucidate the potential mechanism.

Naringin protects the nigrostriatal dopaminergic projection through induction of GDNF in a neurotoxin model of Parkinson's disease.

Eunju Leem et al.

The Journal of nutritional biochemistry, 25(7), 801-806 (2014-05-07)

This study investigated the effect of naringin, a major flavonoid in grapefruit and citrus fruits, on the degeneration of the nigrostriatal dopaminergic (DA) projection in a neurotoxin model of Parkinson's disease (PD) in vivo and the potential underlying mechanisms focusing

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货号	GTIN
Y0001378	04061833807552