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Merck
CN

BP739

辛伐他汀

British Pharmacopoeia (BP) Reference Standard

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关于此项目

经验公式（希尔记法）:
C25H38O5
化学文摘社编号:
79902-63-9
分子量:
418.57
UNSPSC Code:
41116107
NACRES:
NA.24
MDL number:
MFCD00072007

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产品名称

辛伐他汀, British Pharmacopoeia (BP) Reference Standard

InChI

1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1

SMILES string

[H][C@]12[C@H](C[C@@H](C)C=C1C=C[C@H](C)[C@@H]2CC[C@@H]3C[C@@H](O)CC(=O)O3)OC(=O)C(C)(C)CC

InChI key

RYMZZMVNJRMUDD-HGQWONQESA-N

grade

pharmaceutical primary standard

API family

simvastatin

form

powder

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

BP

mp

127-132 °C (lit.)

application(s)

pharmaceutical
pharmaceutical small molecule

format

neat

storage temp.

−20°C

Gene Information

human ... HMGCR(3156)

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相关类别

Biochem/physiol Actions

辛伐他汀是HMG-CoA还原酶和降胆固醇药物的特异性抑制剂。
辛伐他汀是HMG-CoA还原酶的特异性抑制剂，HMG-CoA还原酶是催化HMG-CoA转化为甲羟戊酸的酶，其是胆固醇生物合成的早期步骤。由于它可以降低低密度脂蛋白和甘油三酯的水平，并提高高密度脂蛋白水平，因而可用于治疗高胆固醇血症。辛伐他汀是一种内酯，其在体内 易于水解成相应的β-羟基酸，并可以在使用前用溶于EtOH中的NaOH进行活化。它是洛伐他汀的合成类似物（货M2147）。

Application

Simvastatin BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:
  • Simvastatin Tablets
  • Simvastatin Oral Suspension

    • General description

    This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

    Other Notes

    Sales restrictions may apply.
    Learn how British Pharmacopoeia (BP) sets the standard by offering quality British Pharmacopoeia Chemical Reference Substances (BPCRS).

    Packaging

    Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

    pictograms

    Health hazard
    GHS08

    signalword

    Warning

    hcodes

    H361d

    Hazard Classifications

    Repr. 2

    存储类别

    11 - Combustible Solids

    wgk

    WGK 3

    flash_point_f

    Not applicable

    flash_point_c

    Not applicable

    历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number

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