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Merck
CN

C5548

丁酸氯倍他松

≥98% purity, powder

别名:

21-Chloro-9-fluoro-17-hydroxy-16-methylpregna-1,4-diene-3,11,20-trione 17-butyrate

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关于此项目

经验公式（希尔记法）:
C26H32ClFO5
化学文摘社编号:
25122-57-0
分子量:
478.98
NACRES:
NA.47
PubChem Substance ID:
329775093
UNSPSC Code:
12171500
EC Number:
246-635-9
MDL number:
MFCD00133196

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产品名称

丁酸氯倍他松, ≥98%

InChI key

FBRAWBYQGRLCEK-AVVSTMBFSA-N

InChI

1S/C26H32ClFO5/c1-5-6-22(32)33-26(21(31)14-27)15(2)11-19-18-8-7-16-12-17(29)9-10-23(16,3)25(18,28)20(30)13-24(19,26)4/h9-10,12,15,18-19H,5-8,11,13-14H2,1-4H3/t15-,18-,19-,23-,24-,25-,26-/m0/s1

SMILES string

CCCC(=O)O[C@@]1([C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)C(=O)C[C@]12C)C(=O)CCl

assay

≥98%

form

powder

color

white to faint yellow cast

mp

90-100 °C

solubility

chloroform: 50 mg/mL, clear, faintly yellow

ε (extinction coefficient)

13.4 at 243 nm in chloroform

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

Quality Level

200

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相关类别

Application

Clobetasone butyrate has been used as an internal standard for the quantitative assay of clobetasol propionate.
Clobetasone butyrate has been used to analyze its bio-concentration factor (BCF) in Cyprinus carpio.

Biochem/physiol Actions

Clobetasone butyrate is a potent topical corticosteroid and is primarily used to treat atopic dermatitis (AD). Low dosage of this drug is used to treat dry eye in Sjogrens syndrome.

General description

Clobetasone butyrate is a corticosteroid.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
080H0754
080H0759

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Liquid chromatography--tandem mass spectrometric assay for clobetasol propionate in human serum from patients with atopic dermatitis
Sparidans RW, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 878(23), 2150-2154 (2010)
Community Pharmacy - E-Book: Symptoms Diagnosis and Treatment (2011)
Safety and efficacy of 0.1% clobetasone butyrate eyedrops in the treatment of dry eye in Sjogren syndrome
Aragona P, et al.
European Journal of Ophthalmology, 23(3) (2013)
Uptake and biological effects of synthetic glucocorticoids in common carp (Cyprinus carpio)
Nakayama K, et al.
Marine Pollution Bulletin, 85(2), 370-375 (2014)
Fluticasone propionate 0.05% cream once daily versus clobetasone butyrate 0.05% cream twice daily in children with atopic dermatitis
Wolkerstorfer A, et al.
Journal of the American Academy of Dermatology, 39(2), 226-231 (1998)
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