D1065
4-(2-[6-(二辛基氨基)-2-萘基]乙烯基)-1-(3-磺丙基)吡啶鎓 内盐
≥95% purity (HPLC), solid
别名:
Di-8-ANEPPS
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选择尺寸
关于此项目
经验公式（希尔记法）:
C36H52N2O3S
化学文摘社编号:
分子量:
592.87
UNSPSC Code:
12171500
PubChem Substance ID:
NACRES:
NA.47
MDL number:
产品名称
4-(2-[6-(二辛基氨基)-2-萘基]乙烯基)-1-(3-磺丙基)吡啶鎓 内盐, ≥95% (HPLC), solid
SMILES string
CCCCCCCCN(CCCCCCCC)c1ccc2cc(\C=C\c3cc[n+](CCCS([O-])(=O)=O)cc3)ccc2c1
InChI key
IXFSUSNUALIXLU-UHFFFAOYSA-N
InChI
1S/C36H52N2O3S/c1-3-5-7-9-11-13-25-38(26-14-12-10-8-6-4-2)36-21-20-34-30-33(18-19-35(34)31-36)17-16-32-22-27-37(28-23-32)24-15-29-42(39,40)41/h16-23,27-28,30-31H,3-15,24-26,29H2,1-2H3
assay
≥95% (HPLC)
form
solid
mol wt
592.88
color
orange to red
solubility
DMSO: soluble
ethanol: soluble
ε (extinction coefficient)
≥37 at 495-501 nm in methanol
fluorescence
λex 710-716 nm
application(s)
diagnostic assay manufacturing
hematology
histology
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
一种快速响应的膜电位染料。
Other Notes
可在细胞质膜外叶滞留更久，因此比di-4-ANEPPS（货号D8064）更适合长时程膜电位研究。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Kirby R Campbell et al.
The journal of physical chemistry. B, 121(8), 1749-1757 (2017-02-09)
Extensive remodeling of the extracellular matrix (ECM) occurs in many epithelial cancers. For example, in ovarian cancer, upregulation of collagen isoform type III has been linked to invasive forms of the disease, and this change may be a potential biomarker.
Antonio Celestino-Montes et al.
Life sciences, 264, 118700-118700 (2020-11-02)
Ventricular myocytes (VM) depolarization activates L-type Ca2+ channels (LCC) allowing Ca2+ influx (ICa) to synchronize sarcoplasmic reticulum (SR) Ca2+ release, via Ca2+-release channels (RyR2). The resulting whole-cell Ca2+ transient triggers contraction, while cytosolic Ca2+ removal by SR Ca2+ pump (SERCA2)
S Antić et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 15(2), 1392-1405 (1995-02-01)
We carried out experiments to monitor optically the generation and spread of action potentials and subthreshold potentials in the processes of individual neurons in ganglia of the snail, Helix aspersa. The neurons were selectively stained by intracellular pressure injection of
Sanaya N Shroff et al.
iScience, 23(4), 100974-100974 (2020-04-17)
Precise measurement of action potentials (APs) is needed to observe electrical activity and cellular communication within cardiac tissue. Voltage-sensitive dyes (VSDs) are traditionally used to measure cardiac APs; however, they require acute chemical addition that prevents chronic imaging. Genetically encoded
Carlos A Valverde et al.
Cardiovascular research, 115(3), 556-569 (2018-09-01)
Abnormal Ca2+ release from the sarcoplasmic reticulum (SR), associated with Ca2+-calmodulin kinase II (CaMKII)-dependent phosphorylation of RyR2 at Ser2814, has consistently been linked to arrhythmogenesis and ischaemia/reperfusion (I/R)-induced cell death. In contrast, the role played by SR Ca2+ uptake under
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