D1065
4-(2-[6-(二辛基氨基)-2-萘基]乙烯基)-1-(3-磺丙基)吡啶鎓 内盐
≥95% purity (HPLC), solid
别名:
Di-8-ANEPPS
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关于此项目
经验公式（希尔记法）:
C36H52N2O3S
化学文摘社编号:
分子量:
592.87
MDL编号:
UNSPSC代码:
12171500
PubChem化学物质编号:
NACRES:
NA.47
产品名称
4-(2-[6-(二辛基氨基)-2-萘基]乙烯基)-1-(3-磺丙基)吡啶鎓 内盐, ≥95% (HPLC), solid
质量水平
方案
≥95% (HPLC)
表单
solid
分子量
592.88
颜色
orange to red
溶解性
DMSO: soluble
ethanol: soluble
ε (消光系数)
≥37 at 495-501 nm in methanol
荧光
λex 710-716 nm
应用
diagnostic assay manufacturing
hematology
histology
储存温度
2-8°C
SMILES字符串
CCCCCCCCN(CCCCCCCC)c1ccc2cc(\C=C\c3cc[n+](CCCS([O-])(=O)=O)cc3)ccc2c1
InChI
1S/C36H52N2O3S/c1-3-5-7-9-11-13-25-38(26-14-12-10-8-6-4-2)36-21-20-34-30-33(18-19-35(34)31-36)17-16-32-22-27-37(28-23-32)24-15-29-42(39,40)41/h16-23,27-28,30-31H,3-15,24-26,29H2,1-2H3
InChI key
IXFSUSNUALIXLU-UHFFFAOYSA-N
生化/生理作用
一种快速响应的膜电位染料。
其他说明
可在细胞质膜外叶滞留更久，因此比di-4-ANEPPS（货号D8064）更适合长时程膜电位研究。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
S Antić et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 15(2), 1392-1405 (1995-02-01)
We carried out experiments to monitor optically the generation and spread of action potentials and subthreshold potentials in the processes of individual neurons in ganglia of the snail, Helix aspersa. The neurons were selectively stained by intracellular pressure injection of
Kirby R Campbell et al.
The journal of physical chemistry. B, 121(8), 1749-1757 (2017-02-09)
Extensive remodeling of the extracellular matrix (ECM) occurs in many epithelial cancers. For example, in ovarian cancer, upregulation of collagen isoform type III has been linked to invasive forms of the disease, and this change may be a potential biomarker.
Antonio Celestino-Montes et al.
Life sciences, 264, 118700-118700 (2020-11-02)
Ventricular myocytes (VM) depolarization activates L-type Ca2+ channels (LCC) allowing Ca2+ influx (ICa) to synchronize sarcoplasmic reticulum (SR) Ca2+ release, via Ca2+-release channels (RyR2). The resulting whole-cell Ca2+ transient triggers contraction, while cytosolic Ca2+ removal by SR Ca2+ pump (SERCA2)
Carlos A Valverde et al.
Cardiovascular research, 115(3), 556-569 (2018-09-01)
Abnormal Ca2+ release from the sarcoplasmic reticulum (SR), associated with Ca2+-calmodulin kinase II (CaMKII)-dependent phosphorylation of RyR2 at Ser2814, has consistently been linked to arrhythmogenesis and ischaemia/reperfusion (I/R)-induced cell death. In contrast, the role played by SR Ca2+ uptake under
Sanaya N Shroff et al.
iScience, 23(4), 100974-100974 (2020-04-17)
Precise measurement of action potentials (APs) is needed to observe electrical activity and cellular communication within cardiac tissue. Voltage-sensitive dyes (VSDs) are traditionally used to measure cardiac APs; however, they require acute chemical addition that prevents chronic imaging. Genetically encoded
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