D8064
氢氧化4-(2-(6-(二丁基氨基)-2-萘基)乙烯基)-1-(3-磺丙基)吡啶鎓 内盐
≥95% purity (HPLC), solid
别名:
Di-4-ANEPPS
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关于此项目
经验公式（希尔记法）:
C28H36N2O3S
化学文摘社编号:
分子量:
480.66
UNSPSC Code:
12171500
PubChem Substance ID:
NACRES:
NA.47
MDL number:
产品名称
氢氧化4-(2-(6-(二丁基氨基)-2-萘基)乙烯基)-1-(3-磺丙基)吡啶鎓 内盐, ≥95% (HPLC), solid
SMILES string
CCCCN(CCCC)c1ccc2cc(\C=C\c3cc[n+](CCCS([O-])(=O)=O)cc3)ccc2c1
InChI key
HAPJROQJVSPKCJ-UHFFFAOYSA-N
InChI
1S/C28H36N2O3S/c1-3-5-17-30(18-6-4-2)28-13-12-26-22-25(10-11-27(26)23-28)9-8-24-14-19-29(20-15-24)16-7-21-34(31,32)33/h8-15,19-20,22-23H,3-7,16-18,21H2,1-2H3
assay
≥95% (HPLC)
form
solid
mol wt
480.66
technique(s)
titration: suitable
color
orange to dark red
solubility
DMF: soluble, DMSO: soluble, ethanol: soluble
ε (extinction coefficient)
≥38000 at 493-499 nm in methanol
application(s)
diagnostic assay manufacturing
hematology
histology
storage temp.
2-8°C
Quality Level
Application
氢氧化 4-(2-(6-(二丁基氨基)-2-萘基)乙烯基)-1-(3-硫代丙基)吡啶正离子内盐已用作心脏细胞中的电压敏感染料。
Biochem/physiol Actions
膜电位染料，可响应在 440 和 505 nm 处荧光激发监测的膜电位的变化；与细胞膜电位的变化有关。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
J M Davidenko et al.
Nature, 355(6358), 349-351 (1992-01-23)
Excitable media can support spiral waves rotating around an organizing centre. Spiral waves have been discovered in different types of autocatalytic chemical reactions and in biological systems. The so-called 're-entrant excitation' of myocardial cells, causing the most dangerous cardiac arrhythmias
G Bub et al.
American journal of physiology. Heart and circulatory physiology, 298(5), H1616-H1625 (2010-03-17)
Sarcomere length (SL) is an important determinant and indicator of cardiac mechanical function; however, techniques for measuring SL in living, intact tissue are limited. Here, we present a technique that uses two-photon microscopy to directly image striations of living cells
Engineering a freestanding biomimetic cardiac patch using biodegradable poly(lactic-co-glycolic acid) (PLGA) and human embryonic stem cell-derived ventricular cardiomyocytes (hESC-VCMs).
Chen Y, et al.
Macromolecular Bioscience, 15, 426-436 (2015)
P Fromherz et al.
Biochimica et biophysica acta, 1068(2), 149-156 (1991-09-30)
The voltage sensitivity of fluorescence of an aminobenzstyryl-pyridinium dye (di4-ANEPPS) is characterized in Retzius cells dissociated from the leech. The modulation of the complete spectra of excitation and emission is determined. The spectral changes induced by depolarization are described by
Zachary Laksman et al.
Scientific reports, 7(1), 5268-5268 (2017-07-15)
Since current experimental models of Atrial Fibrillation (AF) have significant limitations, we used human embryonic stem cells (hESCs) to generate an atrial-specific tissue model of AF for pharmacologic testing. We generated atrial-like cardiomyocytes (CMs) from hESCs which preferentially expressed atrial-specific
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