F6377
荧光素 钠盐
Powder
别名:
D&C;黄色8号, 荧光素钠, 酸性黄 73
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关于此项目
经验公式（希尔记法）:
C20H10Na2O5
化学文摘社编号:
分子量:
376.27
UNSPSC Code:
12171500
NACRES:
NA.47
PubChem Substance ID:
EC Number:
208-253-0
MDL number:
Colour Index Number:
45350
Beilstein/REAXYS Number:
3833041
产品名称
荧光素 钠盐, used as fluorescent tracer
InChI
1S/C20H12O5.2Na/c21-11-5-7-15-17(9-11)24-18-10-12(22)6-8-16(18)20(15)14-4-2-1-3-13(14)19(23)25-20;;/h1-10,21-22H;;/q;2*+1/p-2
SMILES string
[Na+].[Na+].[O-]c1ccc2c(Oc3cc([O-])ccc3C24OC(=O)c5ccccc45)c1
InChI key
RGPLGPBQJOQFJS-UHFFFAOYSA-L
form
powder
technique(s)
titration: suitable
pH
8.3 (20 °C, 10 g/L)
mp
>300 °C
solubility
H2O: 1 mg/mL
density
0.78 g/cm3 at 29.6 °C (85.3 °F at 699.7 hPa)
fluorescence
λex 460 nm; λem 515 nm(lit.)
application(s)
diagnostic assay manufacturing
hematology
histology
storage temp.
room temp
Quality Level
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Application
荧光素钠盐被用作一种溶质，用于研究微血管渗透性。它已被用作研究血液屏障穿透性的测试分子。
水溶性荧光染料由于其分子半径小，渗透性和血管灌注研究中得到应用。 以荧光素钠作为荧光示踪剂，用于研究血脑屏障(BBB)和血脊髓屏障(BSCB)在啮齿类动物模型中的通透性。 以该染料为探针底物，研究了有机阴离子转运多肽(OATP)介导的肝细胞药物转运。荧光素钠还被应用于光致退色后 原位 溶质通过荧光恢复进入骨内。
General description
荧光素是一种黄嘌呤染料，是生物学中常用的标记试剂。
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
423.7 °F - Pensky-Martens closed cup
flash_point_c
217.6 °C - Pensky-Martens closed cup
ppe
Eyeshields, Gloves, type N95 (US)
Tom De Bruyn et al.
Journal of pharmaceutical sciences, 100(11), 5018-5030 (2011-08-13)
The aim of this study was to characterize the in vitro hepatic uptake kinetics of sodium fluorescein (NaFluo) and identify the transporters involved. NaFluo exhibited saturable uptake kinetics in suspended rat and human hepatocytes as reflected by K(m) values of
Electrical conductivity and dielectric relaxation behavior of fluorescein sodium salt (FSS).
Mansour SA, et al.
Solid State Communications, 150(29), 1386-1391 (2010)
Structural mechanisms of acute VEGF effect on microvessel permeability.
American Journal of Physiology. Heart and Circulatory Physiology, 284, H2124-H2124 (2003)
In vitro model of the outer blood-retina barrier.
Steuer H
Brain Research. Brain Research Protocols, 13, 26-26 (2004)
R Oishi et al.
Naunyn-Schmiedeberg's archives of pharmacology, 339(1-2), 159-165 (1989-01-01)
Morphine (5 mg/kg, s.c.) caused a submaximal increase in the brain level of sodium fluorescein administered i.v. Histamine H1-antagonists, diphenhydramine and mepyramine, given either i.p. or i.c.v., had no significant influence on the effect of morphine. H2-Antagonists, cimetidine and ranitidine
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