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经验公式（希尔记法）:
C9H16ClN3O2
化学文摘社编号:
分子量:
233.70
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
产品名称
洛莫司汀, European Pharmacopoeia (EP) Reference Standard
InChI
1S/C9H16ClN3O2/c10-6-7-13(12-15)9(14)11-8-4-2-1-3-5-8/h8H,1-7H2,(H,11,14)
SMILES string
ClCCN(N=O)C(=O)NC1CCCCC1
InChI key
GQYIWUVLTXOXAJ-UHFFFAOYSA-N
grade
pharmaceutical primary standard
API family
lomustine
manufacturer/tradename
EDQM
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
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Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
Application
Lomustine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
Biochem/physiol Actions
Antineoplastic agent with cellular DNA effects. Lomustine induces p53 expression in A2870 cells.
General description
Nitrosamines are chemical compounds that can form during drug manufacturing and may pose health risks, including carcinogenicity.
This product is provided as delivered and specified by the issuing Pharmacopoeia. For further information and support, including certificate/ product information sheets, please go to the website of the issuing Pharmacopoeia.
This product is provided as delivered and specified by the issuing Pharmacopoeia. For further information and support, including certificate/ product information sheets, please go to the website of the issuing Pharmacopoeia.
Other Notes
Sales restrictions may apply.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Carc. 1B
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Preliminary study of lomustine in the treatment of intracranial masses in dogs following localization by imaging techniques.
L M Fulton et al.
Seminars in veterinary medicine and surgery (small animal), 5(4), 241-245 (1990-11-01)
The role of an all-oral chemotherapy containing lomustine (CCNU) in advanced,fs progressive Hodgkin lymphoma: a patient-friendly palliative option which can result in long-term disease control.
S J Proctor et al.
Annals of oncology : official journal of the European Society for Medical Oncology, 21(2), 426-428 (2009-11-11)
G A Kaltsas et al.
Clinical endocrinology, 57(2), 169-183 (2002-08-03)
Combination chemotherapy with the two agents streptozotocin (SZT), which is a nitrosurea, and 5-fluorouracil (5-FU), an alkylating agent, has a long-established role in the treatment of neuroendocrine tumours; however, it is often accompanied by considerable toxicity, and it has not
The nitrosoureas: carmustine (BCNU) and lomustine (CCNU).
R B Weiss et al.
Cancer treatment reviews, 9(4), 313-330 (1982-12-01)
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