Merck
CN
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文件

L0745000

洛莫司汀

European Pharmacopoeia (EP) Reference Standard

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别名:
1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea
经验公式（希尔记法）:
C9H16ClN3O2
CAS号:
13010-47-4
分子量:
233.70
MDL编号:
MFCD00012392
PubChem化学物质编号:
329817373
NACRES:
NA.24

等级

pharmaceutical primary standard

API family

lomustine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

SMILES string

ClCCN(N=O)C(=O)NC1CCCCC1

InChI

1S/C9H16ClN3O2/c10-6-7-13(12-15)9(14)11-8-4-2-1-3-5-8/h8H,1-7H2,(H,11,14)

InChI key

GQYIWUVLTXOXAJ-UHFFFAOYSA-N

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相关类别

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Lomustine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

生化/生理作用

Antineoplastic agent with cellular DNA effects. Lomustine induces p53 expression in A2870 cells.

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险声明

H301 - H350

预防措施声明

P201 - P301 + P310 + P330

危险分类

Acute Tox. 3 Oral - Carc. 1B

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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Preliminary study of lomustine in the treatment of intracranial masses in dogs following localization by imaging techniques.
L M Fulton et al.
Seminars in veterinary medicine and surgery (small animal), 5(4), 241-245 (1990-11-01)
The nitrosoureas: carmustine (BCNU) and lomustine (CCNU).
R B Weiss et al.
Cancer treatment reviews, 9(4), 313-330 (1982-12-01)
The role of an all-oral chemotherapy containing lomustine (CCNU) in advanced,fs progressive Hodgkin lymphoma: a patient-friendly palliative option which can result in long-term disease control.
S J Proctor et al.
Annals of oncology : official journal of the European Society for Medical Oncology, 21(2), 426-428 (2009-11-11)
G A Kaltsas et al.
Clinical endocrinology, 57(2), 169-183 (2002-08-03)
Combination chemotherapy with the two agents streptozotocin (SZT), which is a nitrosurea, and 5-fluorouracil (5-FU), an alkylating agent, has a long-established role in the treatment of neuroendocrine tumours; however, it is often accompanied by considerable toxicity, and it has not

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