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M2305000

米托蒽醌 盐酸盐

European Pharmacopoeia (EP) Reference Standard

Synonym(s):
米托蒽醌 二盐酸盐, 1,4-二羟基-5,8-双-[[2-[(2-羟乙基)氨基] 乙基] 氨基]-9,10-蒽二酮 二盐酸盐
Empirical Formula (Hill Notation):
C22H28N4O6 · 2HCl
CAS Number:
Molecular Weight:
517.40
MDL编号:
PubChem化学物质编号:
NACRES:
NA.24

等级

pharmaceutical primary standard

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

SMILES string

Cl[H].Cl[H].OCCNCCNc1ccc(NCCNCCO)c2C(=O)c3c(O)ccc(O)c3C(=O)c12

InChI

1S/C22H28N4O6.2ClH/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32;;/h1-4,23-30H,5-12H2;2*1H

InChI key

ZAHQPTJLOCWVPG-UHFFFAOYSA-N

Gene Information

human ... TOP2A(7153)

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一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

米托蒽醌是一种细胞抑制性蒽二酮,可嵌入 DNA 中,通过稳定拓扑异构酶 II 与 DNA 的可裂解复合物,增加双链断裂的发生率。米托蒽醌还表现出广泛的免疫抑制活性,抑制各类淋巴细胞增殖并诱导抗原提呈 T 细胞凋亡。它在临床上用作抗白血病和实体瘤的化疗药物以及多发性硬化症的免疫系统调节剂。

包装

Unit quantity: 60 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

其他说明

Sales restrictions may apply.

象形图

Health hazard

警示用语:

Danger

危险声明

预防措施声明

危险分类

Muta. 1B - Repr. 1B

储存分类代码

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

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SDS

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