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Merck
CN

M6035

4-（N-马来酰亚胺甲基）环己烷-1-羧酸3-磺基-N-羟基琥珀酰亚胺酯 钠盐

powder

别名:

Sulfo-SMCC

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关于此项目

经验公式（希尔记法）:
C16H17N2NaO9S
化学文摘社编号:
92921-24-9
分子量:
436.37
NACRES:
NA.47
PubChem Substance ID:
24897071
UNSPSC Code:
12171500
MDL number:
MFCD00054978

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产品名称

4-（N-马来酰亚胺甲基）环己烷-1-羧酸3-磺基-N-羟基琥珀酰亚胺酯 钠盐, powder

InChI

1S/C16H18N2O9S.Na/c19-12-5-6-13(20)17(12)8-9-1-3-10(4-2-9)16(23)27-18-14(21)7-11(15(18)22)28(24,25)26;/h5-6,9-11H,1-4,7-8H2,(H,24,25,26);/q;+1/p-1

SMILES string

O=C(N1CC2CCC(C(ON3C(CC(S(=O)(O[Na])=O)C3=O)=O)=O)CC2)C=CC1=O

InChI key

VUFNRPJNRFOTGK-UHFFFAOYSA-M

form

powder

reaction suitability

reagent type: linker

technique(s)

titration: suitable

color

white to light brown

solubility

H2O: 2.5 mg/mL
DMF: soluble

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

2-8°C

Quality Level

300

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相关类别

Analysis Note

可能含有二甲基甲酰胺。

Biochem/physiol Actions

4-(N-马来酰亚胺甲基)环己烷-1-羧酸3-磺基-N-羟基琥珀酰亚胺酯钠盐可将确定数目的马来酰亚胺基引入蛋白质，使其在低温下具有较长的保质期，并可进一步标记上氟-18[18F]。

General description

4-(N-马来酰亚胺甲基)环己烷-1-羧酸3-磺基-N-羟基琥珀酰亚胺酯钠盐(sulfoSMCC)是一种异双功能蛋白质/多肽交联剂和合用的交叉偶联试剂。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
WXBF3455V
WXBF3025V
WXBF4082V
WXBF0912V
WXBF2308V

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Marc Rigau et al.
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Renshaw S
Immunohistochemistry and Immunocytochemistry: Essential Methods (2017)
Robert K Strother et al.
Journal of immunology (Baltimore, Md. : 1950), 197(11), 4301-4311 (2016-11-01)
Patients surviving acute stages of sepsis often display impaired adaptive-immune responses. Using the cecal ligation and puncture model, we demonstrated that sepsis leads to substantial and long-lasting changes in the naive CD8 T cell repertoire, affecting the capacity of the
Cláudia S M Fernandes et al.
Biotechnology journal, 11(12), 1513-1524 (2016-08-06)
Retroviral particles are expensive to manufacture, mostly due to the downstream processing steps which result in low recoveries (≈30%) and concentration factors. In this work, a dodecapeptide phage-display library was panned against retrovirus like particles expressing the envelope protein Ampho4070A
Protein labeling with the labeling precursor [(18)F]SiFA-SH for positron emission tomography.
Wangler B
Nature Protocols, 7, 1964-1964 (2012)
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