主要文件

查看所有文档

PHI90004

D-谷氨酸(第17位）修饰多肽结构变体

Name: D-谷氨酸(第17位）修饰多肽结构变体
Brand: SIAL

GLP-1 Agonist Impurity, analytical standard, Numbering in the name as per API

别名:

D-Glu-(23)-Liraglutide, H-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-D-Glu-Ala-Ala-Lys (γ-Glu-Palmitoyl)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH

登录并加购，请在购物车里查看协议价、货期和发货地。

选择规格

变更视图

关于此项目

经验公式（希尔记法）:

C₁₇₂H₂₆₄N₄₂O₅₂

分子量:

3752.19

UNSPSC Code:

41116107

技术服务

需要帮助？我们经验丰富的科学家团队随时乐意为您服务。

让我们为您提供帮助

属性

grade

analytical standard

Quality Segment

100

API family

liraglutide, liraglutide, liraglutide, liraglutide

form

powder

technique(s)

HPLC: suitable, LC/MS: suitable, liquid chromatography (LC): suitable, mass spectrometry (MS): suitable

color

white to off-white

format

neat

storage temp.

−20°C

SMILES string

OC[C@@H](C(N[C@@H](CC1=CC=C(O)C=C1)C(N[C@@H](CC(C)C)C(N[C@@H](CC C(O)=O)C(NCC(N[C@H](CCC(O)=O)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CCCCNC(CC [C@@H](C(O)=O)NC(CCCCCCCCCCCCCCC)=O)=O)C(N[C@H](C(N[C@H](C(N [C@@H]([C@@H](C)CC)C(N[C@H](C(N[C@@H](CC2=CNC3=CC=CC=C23)C(N[C@@H](CC(C) C)C(N[C@@H](C(C)C)C(N[C@H](C(NCC(N[C@H](C(NCC(O)=O)=O)CCCNC( N)=N)=O)=O)CCCNC(N)=N)=O)=O)=O)=O)C)=O)=O)CC4=CC=CC=C4)=O)CCC(O)=O)=O)=O )=O)=O)=O)=O)=O)=O)=O)NC([C@H](CO)NC([C@H](C(C)C)NC([C@H](CC (O)=O)NC([C@H](CO)NC([C@H]([C@H](O)C)NC([C@H](CC5=CC=CC=C5)N C([C@H]([C@H](O)C)NC(CNC([C@H](CCC(O)=O)NC([C@H](C)NC([C@H](CC6=CNC=N6)N )=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

说明

General description

D-Glu(17)-Liraglutide is a stereoisomeric impurity of Liraglutide characterised by the replacement of L-Glutamic acid at position 17 (API numbering; position 17 in GLP-1 numbering) with its D-enantiomer (D-Glu). Position 17 resides within the central α-helical domain of the peptide, and its stereoinversion may perturb helix stability and receptor contact surface. The impurity is otherwise structurally identical to Liraglutide, retaining the palmitoyl–γGlu–Lys26 fatty acid conjugate. Racemisation at Glu residues during SPPS, particularly under prolonged activation or elevated temperature, is a recognised source of this impurity type.

Application

Used as an analytical standard for the identification and semi-quantification of the D-Glu17 diastereomeric impurity in Liraglutide API by reversed-phase HPLC, chiral chromatography, and LC-MS/MS methods.

存储类别

11 - Combustible Solids

闪点 (F)

Not applicable

闪点 (°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库