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安全信息

PHR1005

Supelco

对乙酰氨基酚

Pharmaceutical Secondary Standard; Certified Reference Material

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别名:
4′-羟基乙酰苯胺, 4-乙酰氨基酚, N-(4-羟基苯基)乙酰胺, N-乙酰基-4-氨基苯酚, APAP, 扑热息痛
线性分子式:
CH3CONHC6H4OH
CAS号:
103-90-2
分子量:
151.16
Beilstein:
2208089
EC 号:
203-157-5
MDL编号:
MFCD00002328
PubChem化学物质编号:
329823036
NACRES:
NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to BP 371
traceable to Ph. Eur. P030000
traceable to USP 1003009

API类

paracetamol, acetaminophen

CofA

current certificate can be downloaded

技术

HPLC: suitable
gas chromatography (GC): suitable

mp

168-172 °C (lit.)

应用

pharmaceutical (small molecule)

格式

neat

储存温度

2-30°C

SMILES字符串

CC(=O)Nc1ccc(O)cc1

InChI

1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)

InChI key

RZVAJINKPMORJF-UHFFFAOYSA-N

基因信息

human ... FAAH(2166) , PTGS1(5742) , PTGS2(5743) , TRPV1(7442)

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相关类别

一般描述

Acetaminophen is a drug, which possesses pharmacological properties like antipyretic and analgesic property.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

应用

Acetaminophen may be used as a standard in the determination of acetaminophen in human serum or plasma samples using spectrophotometric technique. It may also be used as a standard in the estimation of acetaminophen in pharmaceutical formulations using high performance liquid chromatography (HPLC).
镇痛剂。

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAB7782 in the slot below. This is an example certificate only and may not be the lot that you receive.

推荐产品

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

相关产品

产品编号
说明
价格

PHR1148

对乙酰氨基酚相关化合物K, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1149

对乙酰氨基酚相关化合物J, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1150

对乙酰氨基酚相关化合物F, Pharmaceutical Secondary Standard; Certified Reference Material

1003009

对乙酰氨基酚, United States Pharmacopeia (USP) Reference Standard

1021204

4-氨基苯酚, United States Pharmacopeia (USP) Reference Standard

PHR1225

3-氨基苯酚, Pharmaceutical Secondary Standard; Certified Reference Material

1003010

Acetaminophen Related Compound A, United States Pharmacopeia (USP) Reference Standard

P0300000

扑热息痛, European Pharmacopoeia (EP) Reference Standard

PHR1531

对乙酰氨基酚相关化合物C, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1530

对乙酰氨基酚相关化合物D, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1612

对乙酰氨基酚相关化合物A, Pharmaceutical Secondary Standard; Certified Reference Material

1003027

Acetaminophen Related Compound B, United States Pharmacopeia (USP) Reference Standard

1003042

乙酰苯胺, United States Pharmacopeia (USP) Reference Standard

1003100

4'-氯乙酰苯胺, United States Pharmacopeia (USP) Reference Standard

1003031

2-乙酰胺基苯酚, United States Pharmacopeia (USP) Reference Standard

PHR1642

对乙酰氨基酚相关化合物B, Pharmaceutical Secondary Standard; Certified Reference Material

1003064

4-硝基苯酚, United States Pharmacopeia (USP) Reference Standard

1026004

3-氨基苯酚, United States Pharmacopeia (USP) Reference Standard

Y0001781

设备鉴定用扑热息痛, European Pharmacopoeia (EP) Reference Standard

PHR1745

4-氨基苯酚, Pharmaceutical Secondary Standard; Certified Reference Material

BP371

扑热息痛, British Pharmacopoeia (BP) Reference Standard

Y0001945

对乙酰氨基酚杂质J, European Pharmacopoeia (EP) Reference Standard

Y0001955

对乙酰氨基酚杂质K, European Pharmacopoeia (EP) Reference Standard

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

364.3 °F - Pensky-Martens closed cup

闪点(°C)

184.6 °C - Pensky-Martens closed cup

法规信息

监管及禁止进口产品

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Simultaneous high-performance liquid chromatographic stability-indicating analysis of acetaminophen and codeine phosphate in tablets and capsules
Sisco.RW, et al.
Journal of Chromatography A, 348, 253-263 (1985)
Reversed-phase HPLC method for the estimation of acetaminophen, ibuprofen and chlorzoxazone in formulations
Ravisankar.S, et al.
Talanta, 46, 1577-1581 (1998)
Spectrophotometric Screening Method for Acetaminophen in Serum and Plasma
Liu.ZT and Oka.HK
Clinical Chemistry, 26, 69-71 (1980)
Elizabeth A Davis et al.
Current biology : CB, 30(22), 4510-4518 (2020-09-19)
Vagal afferent neuron (VAN) signaling sends information from the gut to the brain and is fundamental in the control of feeding behavior and metabolism [1]. Recent findings reveal that VAN signaling also plays a critical role in cognitive processes, including
S M de Morais et al.
Gastroenterology, 102(2), 577-586 (1992-02-01)
Gilbert's syndrome occurs in 5%-7% of the human population and is caused by an inherited deficiency in the glucuronidation of endogenous bilirubin, resulting in its accumulation and jaundice. The authors of the present study have previously shown that rats with
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