Merck
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文件

PHR1017

Supelco

去氧肾上腺素

Pharmaceutical Secondary Standard; Certified Reference Material

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别名:
(R)-(−)-去氧肾上腺素 盐酸盐, PHE, (R)-(−)-1-(3-羟基苯基)-2-甲氨基乙醇 盐酸盐, (R)-(−)-3-羟基-α-(甲氨基乙基)苄醇 盐酸盐
线性分子式:
HOC6H4CH(CH2NHCH3)OH·HCl
CAS号:
61-76-7
分子量:
203.67
Beilstein:
4158948
EC 号:
200-517-3
MDL编号:
MFCD00012605
PubChem化学物质编号:
329823048

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to BP 284
traceable to Ph. Eur. P1250000
traceable to USP 1533002

API family

phenylephrine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

143-145 °C (lit.)

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

SMILES string

OC1=CC([C@H](CNC)O)=CC=C1.Cl

InChI

1S/C9H13NO2.ClH/c1-10-6-9(12)7-3-2-4-8(11)5-7;/h2-5,9-12H,6H2,1H3;1H/t9-;/m0./s1

InChI key

OCYSGIYOVXAGKQ-FVGYRXGTSA-N

Gene Information

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146)

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相关类别

一般描述

用于质量控制的制药二级标准品，为制药实验室和制造商制备内部工作标准品提供了一种方便、高性价比的替代方案。
盐酸苯肾上腺素归为拟交感神经药物。 通常用作鼻腔减充血剂。

应用

盐酸苯肾上腺素可用作药物参考标准品，通过多种色谱法 和分光光度 技术对药物制剂中的分析物进行测定。
这些二级标准品是经过检验的认证标准物质(CRM)。它们适用于多种分析应用，包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他校准需求。

分析说明

这些二级标准品可多次溯源至美国药典、欧洲药典和英国药典一级标准品（如可用）。

其他说明

该认证参考物质（CRM）根据ISO 17034 和 ISO/IEC 17025进行生产和认证。有关此CRM使用的所有信息均可在分析证书上找到。

附注

若要查看此材料的分析证书示例，请在下面的区域中输入 LRAB7786。这只是一个示例证书，可能与您收到批次的产品无关。

推荐产品

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

相关产品

产品编号
说明
价格

Y0000683

去氧肾上腺素, European Pharmacopoeia (EP) Reference Standard

P1240000

去氧肾上腺素, European Pharmacopoeia (EP) Reference Standard

P1250000

去氧肾上腺素 盐酸盐, European Pharmacopoeia (EP) Reference Standard

1533002

去氧肾上腺素 盐酸盐, United States Pharmacopeia (USP) Reference Standard

PHR1695

去氧肾上腺素相关化合物C, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1712

去氧肾上腺素相关化合物E, Pharmaceutical Secondary Standard; Certified Reference Material

1533046

Phenylephrine Related Compound E, United States Pharmacopeia (USP) Reference Standard

1533035

Phenylephrine Related Compound D, United States Pharmacopeia (USP) Reference Standard

1532950

Phenylephrine bitartrate, United States Pharmacopeia (USP) Reference Standard

1533024

Phenylephrine Related Compound C, United States Pharmacopeia (USP) Reference Standard

1533261

Phenylephrine Related Compound F, United States Pharmacopeia (USP) Reference Standard

1533272

Phenylephrine Related Compound G, United States Pharmacopeia (USP) Reference Standard

BP284

去氧肾上腺素 盐酸盐, British Pharmacopoeia (BP) Reference Standard

PHR2153

2-Hydroxy-N-[(2R)-2-hydroxy-2-(3-hydroxyphenyl)ethyl]-N-methylacetamide, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2151

1,2,3,4-四氢-4,6-二羟基-2-甲基异喹啉盐酸盐, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2148

苯肾上腺素相关化合物D, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2154

N-甲酰基去氧肾上腺素, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2149

去氧肾上腺素相关化合物E, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2150

去氧肾上腺素相关化合物G, Pharmaceutical Secondary Standard; Certified Reference Material

PHR3221

Phenylephrine Bitartrate, pharmaceutical secondary standard, certified reference material

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302 - H317

危险分类

Acute Tox. 4 Oral - Skin Sens. 1B

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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示例

T1503
货号
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25G
包装规格/数量

其它示例：

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

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索取COA

  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

  5. Is (R)-(-)-Phenylephrine hydrochloride the same as L-Phenylephrine hydrochloride?

    (R)-(-)-Phenylephrine hydrochloride is also named l-Phenylephrine hydrochloride (lower case el) or Levophenylephrine hydrochloride.

  6. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Determination of phenylephrine hydrochloride and chlorpheniramine maleate in binary mixture using chemometric-assisted spectrophotometric and high-performance liquid chromatographic-UV methods
Al-Shaalan NH
Journal of Saudi Chemical Society, 14(1), 15-21 (2010)
Degradation of phenylephrine hydrochloride in tablet formulations containing aspirin
Troup AE and Mitchner H
Journal of Pharmaceutical Sciences, 53(4), 375-379 (1964)
Simultaneous high performance liquid chromatographic and derivative ratio spectra spectrophotometry determination of chlorpheniramine maleate and phenylephrine hydrochloride
Erk N and Kartal M
Il Farmaco (Societa Chimica Italiana : 1989), 53(8-9), 617-622 (1998)
Development and validation of a novel RP-HPLC method for simultaneous determination of paracetamol, phenylephrine hydrochloride, caffeine, cetirizine and nimesulide in tablet formulation.
Dewani AP, et al.
Arabian Journal of Chemistry, 8(4), 591-598 (2015)
Edmund Tsui et al.
Experimental eye research, 112, 134-138 (2013-05-25)
The impact of mydriatic agents on the standardized provocation of retinal vascular reactivity has not been systematically investigated. Our aim was to investigate the effect of commonly used mydriatic agents on the provoked vascular response of retinal arterioles. One eye
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