Merck
CN
所有图片(1)

文件

PHR1040

Supelco

萘普生

Pharmaceutical Secondary Standard; Certified Reference Material

登录查看公司和协议定价
所有图片(1)
别名:
NAP, (S)-(+)-2-(6-甲氧基-2-萘基)丙酸
线性分子式:
CH3OC10H6CH(CH3)CO2H
CAS号:
22204-53-1
分子量:
230.26
Beilstein:
3591068
EC 号:
244-838-7
MDL编号:
MFCD00010500
PubChem化学物质编号:
329823070
NACRES:
NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to BP 435
traceable to Ph. Eur. N0250000
traceable to USP 1457301

API family

naproxen

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

152-154 °C (lit.)

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

2-30°C

SMILES string

COc1ccc2cc(ccc2c1)[C@H](C)C(O)=O

InChI

1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)/t9-/m0/s1

InChI key

CMWTZPSULFXXJA-VIFPVBQESA-N

Gene Information

human ... PTGS1(5742) , PTGS2(5743)

正在寻找类似产品? Visit 产品对比指南

相关类别

一般描述

用于质量控制的制药二级标准品，为制药实验室和制造商制备内部工作标准品提供了一种方便、高性价比的替代方案。
萘普生是芳基乙酸类化合物,可用作非甾体类抗炎药 (NSAID)。它可用于治疗疼痛、炎症和僵硬。它还可用于治疗类风湿关节炎和其他肌肉骨骼疼痛症。

应用

萘普生 (Naproxen) 可用作药物参考标准品，用于通过高效液相色谱 (HPLC) 技术测定药物制剂中的分析物。
这些二级标准品是合格的认证标准物质（CRM）。它们适用于多种分析应用，包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他校准需求。

生化/生理作用

非选择性环加氧酶(COX-1 和 COX-2)抑制剂。

分析说明

这些二级标准品可追溯至USP、EP（PhEur）和BP一级标准品。

其他说明

该认证参考物质（CRM）根据ISO 17034和ISO/IEC 17025进行生产和认证。所有关于该CRM的信息都可以在分析证书上找到。

附注

要查看该材料的分析证书示例，请在下面的栏位中输入 LRAA8968。这只是一个示例证书，可能不是您收到的批次。

推荐产品

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

相关产品

产品编号
说明
价格

PHR1165

萘普生 钠, Pharmaceutical Secondary Standard; Certified Reference Material

1457301

萘普生, United States Pharmacopeia (USP) Reference Standard

N0250000

萘普生, European Pharmacopoeia (EP) Reference Standard

Y0000399

萘普生, European Pharmacopoeia (EP) Reference Standard

Y0000631

萘普生杂质L, European Pharmacopoeia (EP) Reference Standard

1457403

萘普生 钠, United States Pharmacopeia (USP) Reference Standard

1457312

6-甲氧基-2-萘甲酸, United States Pharmacopeia (USP) Reference Standard

1457425

6′-甲氧基-2′-萘乙酮, United States Pharmacopeia (USP) Reference Standard

08129

6-甲氧基-2-萘酚, pharmaceutical impurity standard

79584

2-Ethyl-6-methoxynaphthalene, pharmaceutical impurity standard

80713

(1RS)-1-(6-Methoxynaphthalen-2-yl)ethanol, pharmaceutical impurity standard

82170

(R)-(-)-6-甲氧基-α-甲基-2-萘乙酸, pharmaceutical impurity standard

07506

(S)-Naproxen ethyl ester, pharmaceutical impurity standard

80822

(S)-Naproxen methyl ester, pharmaceutical impurity standard

80816

(2S)-2-(5-Chloro-6-methoxynaphthalen-2-yl)propanoic acid, pharmaceutical impurity standard

80821

(2S)-2-(5-Iodo-6-methoxynaphthalen-2-yl)propanoic acid, pharmaceutical impurity standard

80818

(2S)-2-(5-Bromo-6-methoxynaphthalen-2-yl)propanoic acid, pharmaceutical impurity standard

07503

2-溴-6-甲氧基萘, pharmaceutical impurity standard

07499

2-甲氧基萘, pharmaceutical impurity standard

07547

6-甲氧基-2-萘甲酸, pharmaceutical impurity standard

BP435

萘普生, British Pharmacopoeia (BP) Reference Standard

1457436

(R)-(-)-6-甲氧基-α-甲基-2-萘乙酸, United States Pharmacopeia (USP) Reference Standard

PHR2254

萘普生, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2256

Naproxen 1,3-Butylene Glycol Esters, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2219

Naproxen 1,2 Propylene Glycol Esters, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2248

Naproxen 2,3-Butylene Glycol Ester, pharmaceutical secondary standard

PHR2257

萘普生异丙酯, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2524

萘普生杂质N, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2525

萘普生杂质M, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2527

Naproxen Related Compound A, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2526

6-甲氧基-2-萘酚, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2520

Naproxen Impurity B, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2519

Naproxen Impurity C, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2518

(R)-(-)-6-甲氧基-α-甲基-2-萘乙酸, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2523

萘普生相关化合物L, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2530

rac-Naproxen, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2517

萘普生相关化合物K, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2521

萘普生杂质A, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2522

萘普生杂质I, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2528

萘普生杂质F, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2529

萘普生杂质E, Pharmaceutical Secondary Standard; Certified Reference Material

警示用语：

Warning

危险分类

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

为方便起见，与您过往购买产品相关的文件已保存在文档库中。

访问文档库

难以找到您所需的产品或批次号码？

在网站页面上，产品编号会附带包装尺寸/数量一起显示（例如：T1503-25G）。请确保 在“产品编号”字段中仅输入产品编号 (示例: T1503).

示例

T1503
货号
-
25G
包装规格/数量

其它示例：

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

输入内容 1.000309185)

遇到问题？欢迎随时联系我们技术服务 寻求帮助

批号可以在产品标签上"批“ （Lot或Batch）字后面找到。

Aldrich 产品

  • 如果您查询到的批号为 TO09019TO 等，请输入去除前两位字母的批号：09019TO。

  • 如果您查询到的批号含有填充代码（例如05427ES-021），请输入去除填充代码-021的批号：05427ES。

  • 如果您查询到的批号含有填充代码（例如 STBB0728K9），请输入去除填充代码K9的批号：STBB0728。

未找到您寻找的产品？

部分情况下，可能未在线提供COA。如果搜索不到COA，可在线索取。

索取COA

High performance liquid chromatography with photo diode array for separation and analysis of naproxen and esomeprazole in presence of their chiral impurities: enantiomeric purity determination in tablets
Ragab MAA and Eman I
Journal of Chromatography A, 1497, 110-117 (2017)
Simultaneous determination of naproxen, ketoprofen and phenol red in samples from rat intestinal permeability studies: HPLC method development and validation
Zakeri-Milani P, et al.
Journal of Pharmaceutical and Biomedical Analysis, 39(3-4), 624-630 (2005)
Marta L Capone et al.
Journal of the American College of Cardiology, 45(8), 1295-1301 (2005-04-20)
We investigated the occurrence of pharmacodynamic interaction between low-dose aspirin and naproxen. The uncertainty of cardioprotection by naproxen has encouraged its combination with aspirin in patients with arthritis and cardiovascular disease. The incubation of washed platelets with naproxen for 5
D Haupt et al.
Journal of biochemical and biophysical methods, 25(4), 273-284 (1992-12-01)
A column-switching system for fast determination of (R)- and (S)-naproxen in liver microsomes has been developed. The centrifuged sample was injected directly onto a pre-column with octadecylcoated silica. The retained analytes were then directed to an alpha 1-AGP column using
J I Schwartz et al.
Clinical pharmacology and therapeutics, 72(1), 50-61 (2002-08-02)
This study compared directly the renal effects of two selective cyclooxygenase (COX)-2 inhibitors (rofecoxib and celecoxib) with naproxen (dual COX-1/COX-2 inhibitor) and placebo in healthy elderly subjects on a sodium-replete diet. A total of 67 elderly subjects stabilized in the
查看所有相关文献

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门