Merck
CN
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文件

PHR1056

Supelco

甲氧苄啶

Pharmaceutical Secondary Standard; Certified Reference Material

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别名:
2,4-二氨基-5-(3,4,5-三甲氧基苄基)嘧啶, NSC 106568
经验公式（希尔记法）:
C14H18N4O3
CAS号:
738-70-5
分子量:
290.32
Beilstein:
625127
EC 号:
212-006-2
MDL编号:
MFCD00036761
PubChem化学物质编号:
329823086
NACRES:
NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to BP 344
traceable to Ph. Eur. T220000
traceable to USP 1692505

API family

trimethoprim

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

2-30°C

SMILES string

COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC

InChI

1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)

InChI key

IEDVJHCEMCRBQM-UHFFFAOYSA-N

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相关类别

一般描述

用于质量控制的已认证的药物二级标准，为制药实验室和制造商提供了药典基本标准的一种方便且成本效益好的替代品。甲氧苄啶是一种合成的抗菌剂，对大多数需氧革兰氏阴性和革兰氏阳性细菌具有体外抗菌活性。它的作用方式涉及到抑制二氢叶酸还原酶，这是一种可在微生物和真核细胞中催化将二氢叶酸还原为四氢叶酸的酶。

应用

甲氧苄啶可作为药物参考标准品，通过色谱以及可见光和紫外分光光度技术对药物制剂中的分析物进行测定。
这些二级标准品是合格的认证标准物质（CRM）。它们适用于多种分析应用，包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他校准需求。
主要作为抗细菌剂。 二氢叶酸还原酶抑制活性和原核酶选择性。

分析说明

这些二级标准品可追溯至USP、EP（PhEur）和BP一级标准品。

其他说明

该认证参考物质 (CRM) 按照 ISO 17034 和 ISO/IEC 17025 生产和认证。所有关于此 CRM 的信息均记载在分析证书中。

附注

要查看该材料的分析证书示例，请在下面的栏位中输入 LRAA7172。这只是一个示例证书，可能不是您收到的批次。

推荐产品

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

象形图

Exclamation markHealth hazard
GHS07,GHS08

警示用语：

Warning

危险声明

H302 - H361d

危险分类

Acute Tox. 4 Oral - Repr. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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难以找到您所需的产品或批次号码？

在网站页面上，产品编号会附带包装尺寸/数量一起显示（例如：T1503-25G）。请确保 在“产品编号”字段中仅输入产品编号 (示例: T1503).

示例

T1503
货号
-
25G
包装规格/数量

其它示例：

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

输入内容 1.000309185)

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批号可以在产品标签上"批“ （Lot或Batch）字后面找到。

Aldrich 产品

  • 如果您查询到的批号为 TO09019TO 等，请输入去除前两位字母的批号：09019TO。

  • 如果您查询到的批号含有填充代码（例如05427ES-021），请输入去除填充代码-021的批号：05427ES。

  • 如果您查询到的批号含有填充代码（例如 STBB0728K9），请输入去除填充代码K9的批号：STBB0728。

未找到您寻找的产品？

部分情况下，可能未在线提供COA。如果搜索不到COA，可在线索取。

索取COA

  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. Is Trimethoprim stable in solution?

    Triemethoprim in a solution of 52% N,N dimethylacetamide:48% propylene glycol at 50 mg/ml is stable when stored at 25° C. There is only a 10% degradation of trimethoprim under these conditions after 885 days.

  6. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Comparison of trimethoprim molecularly imprinted polymers in bulk and in sphere as the sorbent for solid-phase extraction and extraction of trimethoprim from human urine and pharmaceutical tablet and their determination by high-performance liquid chromatography
Hu SG, et al.
Analytica Chimica Acta, 537(1-2), 215-222 (2005)
Trimethoprim resistance.
Huovinen P
Antimicrobial Agents and Chemotherapy, 31(10), 1451-1456 (1987)
Simultaneous LC determination of trimethoprim and sulphamethoxazole in pharmaceutical formulations
Akay C and Ozkan SA
Journal of Pharmaceutical and Biomedical Analysis, 30(4), 1207-1213 (2002)
Determination of sulfamethoxazole and trimethoprim in pharmaceuticals by visible and UV spectrophotometry
Shamsa F and Amani L
Iranian Journal of Pharmaceutical Research : IJPR, 537(1-2), 31-36 (2010)
Kyuho Han et al.
Nature methods, 11(1), 86-93 (2013-11-12)
Protein concentrations are often regulated by dynamic changes in translation rates. Nevertheless, it has been challenging to directly monitor changes in translation in living cells. We have developed a reporter system to measure real-time changes of translation rates in human
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