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PHR1162

洛哌丁胺盐酸盐

Name: 洛哌丁胺 盐酸盐
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

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别名:

4-（ p -氯苯基）-4-羟基- N,N -二甲基-α,α-二苯基-1-哌啶丁酰胺盐酸盐

经验公式（希尔记法）:

C₂₉H₃₃ClN₂O₂ · HCl

CAS号:

34552-83-5

分子量:

513.50

EC 号:

252-082-4

MDL编号:

MFCD00058581

PubChem化学物质编号:

329823179

NACRES:

NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to BP 635
traceable to Ph. Eur. L0750000
traceable to USP 1370000

API类

loperamide

CofA

current certificate can be downloaded

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

pharmaceutical (small molecule)

格式

neat

储存温度

2-30°C

SMILES字符串

Cl.CN(C)C(=O)C(CCN1CCC(O)(CC1)c2ccc(Cl)cc2)(c3ccccc3)c4ccccc4

InChI

1S/C29H33ClN2O2.ClH/c1-31(2)27(33)29(24-9-5-3-6-10-24,25-11-7-4-8-12-25)19-22-32-20-17-28(34,18-21-32)23-13-15-26(30)16-14-23;/h3-16,34H,17-22H2,1-2H3;1H

InChI key

PGYPOBZJRVSMDS-UHFFFAOYSA-N

基因信息

human ... OPRM1(4988)

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一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Loperamide hydrochloride finds application in the regulation and symptomatic relief of long acting diarrhea linked with inflammatory bowel diseases. It can also be used as a muscle relaxant agent.

应用

Loperamide hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometric and chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Values of analytes vary lot to lot.

附注

To see an example of a Certificate of Analysis for this material enter LRAC3771 in the slot below. This is an example certificate only and may not be the lot that you receive.

1370065

BP635

洛哌丁胺盐酸盐, British Pharmacopoeia (BP) Reference Standard

BP636

Loperamide N-oxide, British Pharmacopoeia (BP) Reference Standard

1370010

系统适用性试验用洛哌丁胺混合物, United States Pharmacopeia (USP) Reference Standard

Y0002087

系统适用性试验用洛哌丁胺, European Pharmacopoeia (EP) Reference Standard

PHR9195

4-(4-氯苯基)-4-羟基哌啶, certified reference material, TraceCERT^®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

PHR2916

象形图

GHS06

警示用语：

Danger

危险声明

H301

预防措施声明

P301 + P310

危险分类

Acute Tox. 3 Oral

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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示例

T1503

货号

25G

包装规格/数量

其它示例：

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

输入内容 1.000309185)

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Spectrofluorimetric and derivative absorption spectrophotometric techniques for the determination of loperamide hydrochloride in pharmaceutical formulations

Hewala II

Journal of Pharmaceutical and Biomedical Analysis, 13(6), 761-767 (1995)

Spectrophotometric determination of loperamide hydrochloride by acid-dye and charge-transfer complexation methods in the presence of its degradation products

El Sherif ZA, et al.

Journal of Pharmaceutical and Biomedical Analysis, 22(1), 13-23 (2000)

Effect of finite doses of propylene glycol on enhancement of in vitro percutaneous permeation of loperamide hydrochloride

Trottet L, et al.

International Journal of Pharmaceutics, 274(1-2), 213-219 (2004)

Garcinia buchananii bark extract is an effective anti-diarrheal remedy for lactose-induced diarrhea.

Paul A Boakye et al.

Journal of ethnopharmacology, 142(2), 539-547 (2012-05-31)

The extract from the stem bark of Garcinia buchananii trees is used as an anti-diarrhea remedy in sub-Saharan Africa. We tested the hypothesis that G. buchananii bark extract and its anti-motility fractions are effective treatments against lactose-induced diarrhea. A high-lactose

Effect of colic vein ligature in rats with loperamide-induced constipation.

Flavia Neri et al.

Journal of biomedicine & biotechnology, 2012, 896162-896162 (2012-06-01)

Medical treatment in chronic constipation is not always successful. Surgery is indicated in unresponsive selected severe cases. This study presents the distal venous colic ligation in rat as a novel surgical approach. 16 rats (study group) were evaluated in 3

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洛哌丁胺 盐酸盐