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PHR1163

（±）-咪康唑硝酸盐

Name: （±）-咪康唑 硝酸盐
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

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别名:

1-（2,4-二氯-β-[（2,4-二氯苄基）氧] 苯乙基 ] 咪唑

经验公式（希尔记法）:

C₁₈H₁₄Cl₄N₂O · HNO₃

CAS号:

22832-87-7

分子量:

479.14

EC 号:

245-256-6

MDL编号:

MFCD00058161

PubChem化学物质编号:

329823180

NACRES:

NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to BP 253
traceable to Ph. Eur. M1900000
traceable to USP 1443500

API family

miconazole

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

2-30°C

SMILES string

ClC1=CC(Cl)=CC=C1C(OCC2=CC=C(Cl)C=C2Cl)CN3C=CN=C3.[O-][N+](O)=O

InChI

1S/C18H14Cl4N2O.HNO3/c19-13-2-1-12(16(21)7-13)10-25-18(9-24-6-5-23-11-24)15-4-3-14(20)8-17(15)22;2-1(3)4/h1-8,11,18H,9-10H2;(H,2,3,4)

InChI key

MCCACAIVAXEFAL-UHFFFAOYSA-N

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一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Miconazole nitrate is an imidazole derivative and a broad spectrum antifungal drug used in the management of fungal outbreak in humans and veterinary animals.

应用

Miconazole nitrate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生化/生理作用

咪康唑与 14-α 相互作用脱甲基酶，一种麦角固醇生物合成所必需的细胞色素 P-450 酶。麦角固醇的抑制导致细胞通透性增加引起细胞内容物渗漏。咪康唑还可能抑制内源性呼吸，与细胞膜中的磷脂相互作用，抑制酵母菌转化为菌丝形式，抑制嘌呤摄取，干扰甘油三酯和磷脂的生物合成。

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Values of analytes vary lot to lot.

附注

To see an example of a Certificate of Analysis for this material enter LRAC3325 in the slot below. This is an example certificate only and may not be the lot that you receive.

1443431

1443464

1443497

BP253

（±）-咪康唑硝酸盐, British Pharmacopoeia (BP) Reference Standard

BP884

咪康唑杂质A, British Pharmacopoeia (BP) Reference Standard

PHR9002

1-[(2RS)-2-(Benzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazolium nitrate, certified reference material, TraceCERT^®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

象形图

GHS07

警示用语：

Warning

危险声明

H302 - H317

预防措施声明

P280 - P301 + P312 + P330 - P302 + P352

危险分类

Acute Tox. 4 Oral - Skin Sens. 1

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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示例

T1503

货号

25G

包装规格/数量

其它示例：

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

输入内容 1.000309185)

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如何查找COA批号

批号可以在产品标签上"批“ （Lot或Batch）字后面找到。

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如果您查询到的批号为 TO09019TO 等，请输入去除前两位字母的批号：09019TO。
如果您查询到的批号含有填充代码（例如05427ES-021），请输入去除填充代码-021的批号：05427ES。
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部分情况下，可能未在线提供COA。如果搜索不到COA，可在线索取。

索取COA

Development of buccal adhesive tablet with prolonged antifungal activity: Optimization and ex vivo deposition studies.

Madgulkar A, et al.

Indian Journal of Pharmaceutical Sciences, 71(3), 290-290 (2009)

Simultaneous determination of miconazole nitrate and metronidazole in different pharmaceutical dosage forms by gas chromatography and flame ionization detector (GC-FID).

Ashour S and Kattan N

International Journal of Biomedical Science : IJBS, 6(1), 13-13 (2010)

Development and validation of a simple stability-indicating high performance liquid chromatographic method for the determination of miconazole nitrate in bulk and cream formulations.

De Zan MM, et al.

Talanta, 79(3), 762-767 (2009)

Simple screening method to identify toxic/non-toxic ionic liquids: agar diffusion test adaptation.

Sónia P M Ventura et al.

Ecotoxicology and environmental safety, 83, 55-62 (2012-06-30)

A wide range of ionic liquids (ILs), containing a diverse set of cations, anions and alkyl chain lengths, was screened for their antimicrobial activity toward four microorganisms, Escherichia coli CCT-0355, Staphylococcus aureus ATCC-6533, Fusarium sp. LM03 and Candida albicans ATCC-76645.

DHEA metabolites activate estrogen receptors alpha and beta.

Kristy K Michael Miller et al.

Steroids, 78(1), 15-25 (2012-11-06)

Dehydroepiandrosterone (DHEA) levels were reported to associate with increased breast cancer risk in postmenopausal women, but some carcinogen-induced rat mammary tumor studies question this claim. The purpose of this study was to determine how DHEA and its metabolites affect estrogen

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（±）-咪康唑 硝酸盐