PHR1200
氯己定杂质P
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
4-氯苯胺
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关于此项目
线性分子式:
ClC6H4NH2
化学文摘社编号:
分子量:
127.57
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
203-401-0
Beilstein/REAXYS Number:
471359
MDL number:
InChI
1S/C6H6ClN/c7-5-1-3-6(8)4-2-5/h1-4H,8H2
SMILES string
Nc1ccc(Cl)cc1
InChI key
QSNSCYSYFYORTR-UHFFFAOYSA-N
grade
certified reference material, pharmaceutical secondary standard
agency
traceable to USP 1111908
vapor density
4.4 (vs air)
vapor pressure
0.15 mmHg ( 25 °C)
API family
proguanil, chlorhexidine
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
bp
232 °C (lit.)
Quality Level
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
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General description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Application
p-Chloroaniline may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Analysis Note
These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.
Other Notes
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC3328 in the slot below. This is an example certificate only and may not be the lot that you receive.
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Skin Sens. 1
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
248.0 °F - closed cup
flash_point_c
120.0 °C - closed cup
法规信息
危险化学品
此项目有
Preparation and evaluation of lidocaine hydrochloride in cyclodextrin inclusion complexes for development of stable gel in association with chlorhexidine gluconate for urogenital use
da Silva LFJS, et al.
International journal of nanomedicine, 6(3), 1143-1143 (2011)
HPLC determination of chlorhexidine gluconate and p-chloroaniline in topical ointment
Havlikova L, et al.
Journal of Pharmaceutical and Biomedical Analysis, 43(3), 1169-1173 (2007)
Fabio Gosetti et al.
Environmental pollution (Barking, Essex : 1987), 158(2), 592-598 (2009-09-22)
This paper studies the degradation reactions that 4-chloroaniline can naturally undergo in waters for the action of sun light. 10.00 mg L(-1) 4-chloroaniline aqueous solution, without any addition of organic solvent, are undergone to photoirradiation under conditions that simulate sun
Fang Wang et al.
Chemical communications (Cambridge, England), (17)(17), 2040-2042 (2008-06-10)
Chemoselective hydrogenation of para-chloronitrobenzene without any dechlorination over Pt/gamma-ZrP catalyst proceeds effectively, which provides a clean and convenient approach to produce useful para-chloroaniline with excellent activity and selectivity.
Brian J Rasimick et al.
Journal of endodontics, 34(12), 1521-1523 (2008-11-26)
The combination of chlorhexidine and EDTA produces a white precipitate. The aim of this study was to determine if the precipitate involves the chemical degradation of chlorhexidine. The precipitate was produced and redissolved in a known amount of dilute trifluoroacetic
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