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Merck
CN

PHR1200

Supelco

氯己定杂质P

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

4-氯苯胺

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关于此项目

线性分子式:
ClC6H4NH2
CAS Number:
分子量:
127.57
Beilstein:
471359
EC 号:
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24
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等级

certified reference material
pharmaceutical secondary standard

质量水平

Agency

traceable to USP 1111908

蒸汽密度

4.4 (vs air)

蒸汽压

0.15 mmHg ( 25 °C)

API类

proguanil, chlorhexidine 

CofA

current certificate can be downloaded

技术

HPLC: suitable
gas chromatography (GC): suitable

沸点

232 °C (lit.)

mp

67-70 °C (lit.)

应用

pharmaceutical (small molecule)

包装形式

neat

储存温度

2-8°C

SMILES字符串

Nc1ccc(Cl)cc1

InChI

1S/C6H6ClN/c7-5-1-3-6(8)4-2-5/h1-4H,8H2

InChI key

QSNSCYSYFYORTR-UHFFFAOYSA-N

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相关类别

一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

应用

p-Chloroaniline may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

分析说明

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC3328 in the slot below. This is an example certificate only and may not be the lot that you receive.

警示用语:

Danger

危险分类

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Skin Sens. 1

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

248.0 °F - closed cup

闪点(°C)

120.0 °C - closed cup

法规信息

危险化学品

分析证书(COA)

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HPLC determination of chlorhexidine gluconate and p-chloroaniline in topical ointment
Havlikova L, et al.
Journal of Pharmaceutical and Biomedical Analysis, 43(3), 1169-1173 (2007)
Preparation and evaluation of lidocaine hydrochloride in cyclodextrin inclusion complexes for development of stable gel in association with chlorhexidine gluconate for urogenital use
da Silva LFJS, et al.
International journal of nanomedicine, 6(3), 1143-1143 (2011)
Luiz Eduardo Barbin et al.
Journal of endodontics, 34(12), 1508-1514 (2008-11-26)
The aim of this study was to determine whether para-chloroaniline (PCA) and/or reactive oxygen species (ROS) are generated by chlorhexidine (CHX) alone or after CHX is mixed with calcium hydroxide at different time points. Mass spectrometry was performed to detect
Liang Zhu et al.
Bioresource technology, 107, 46-54 (2012-01-11)
Because of the important role of extracellular polymeric substances (EPS) in microbial aggregates, the relationship of the EPS and physico-chemical properties of aerobic granule was studied in two sequencing airlift bioreactors (SABR) using two kinds of substrates, acetate+glucose and 4-chloroaniline
John E Thomas et al.
Journal of endodontics, 36(2), 315-317 (2010-02-02)
The purpose of this in vitro study was to determine whether para-chloroaniline (PCA) is formed through the reaction of mixing sodium hypochlorite (NaOCl) and chlorhexidine (CHX). Initially, commercially available samples of chlorhexidine acetate (CHXa) and PCA were analyzed with 1H

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默克Supelco®标准物质不断推出或更新满足海关及法规要求的标准物质。每年我们约有上百种的新CRM或标准物质上市,在此我们尽可能多的列出满足海关及法规要求的标准物质。

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