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PHR1398

倍他米松

Name: 倍他米松
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

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别名:

倍他米松, 9α-氟-11β,17α,21-三羟基-16β-甲基孕甾-1,4-二烯-3,20-二酮, 9α-氟-16β-甲基-11β,17α,21-三羟基-1,4-孕甾二烯-3,20-二酮, 9α-氟-16β-甲基泼尼松龙

经验公式（希尔记法）:

C₂₂H₂₉FO₅

CAS号:

378-44-9

分子量:

392.46

EC 号:

206-825-4

MDL编号:

MFCD00062969

PubChem化学物质编号:

329823372

生物来源

synthetic

质量水平

300

等级

certified reference material
pharmaceutical secondary standard

Agency

BP
EP
USP
traceable to BP 575
traceable to Ph. Eur. B1000000
traceable to USP 1066009

蒸汽压

<0.0000001 kPa ( 25 °C)

API类

betamethasone

CofA

current certificate can be downloaded

包装

pkg of 1 g

储存条件

protect from light (20 mm aluminium crimp seal for unused portion)

技术

HPLC: suitable
gas chromatography (GC): suitable

颜色

white to light yellow

mp

235-237 °C (lit.)

溶解性

acetone: sparingly soluble
chloroform: very slightly soluble
ethanol: sparingly soluble
ether: very slightly soluble
methanol: sparingly soluble
water: insoluble

密度

0.305 g/cm³ at 25 °C (77°F)

应用

pharmaceutical (small molecule)

格式

neat

运输

ambient

储存温度

2-30°C

SMILES字符串

[H][C@@]12C[C@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])CCC4=CC(=O)C=C[C@]34C

InChI

1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1

InChI key

UREBDLICKHMUKA-DVTGEIKXSA-N

基因信息

human ... NR3C1(2908)

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一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Betamethasone belongs to the corticosteriod family of active pharmaceutical ingredients (APIs). It exhibits anti-inflammatory activity and hence is used in the manufacture of various finished pharmaceutical products and is also employed as a starting material to manufacture other APIs that are related to this steroid family.

应用

Betamethasone may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations by using micellar liquid chromatography technique and reversed-phase high-performance liquid chromatography technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAA2174 in the slot below. This is an example certificate only and may not be the lot that you receive.

1067045

1067726

Betamethasone Dipropionate Related Compound B, United States Pharmacopeia (USP) Reference Standard

1067737

Betamethasone Dipropionate Related Compound C, United States Pharmacopeia (USP) Reference Standard

1067760

Betamethasone Dipropionate Related Compound F , United States Pharmacopeia (USP) Reference Standard

1067781

Betamethasone dipropionate Related Compound H, United States Pharmacopeia (USP) Reference Standard

象形图

GHS08

警示用语：

Danger

危险声明

H360FD - H373

预防措施声明

P202 - P260 - P280 - P308 + P313 - P405 - P501

危险分类

Repr. 1B - STOT RE 2

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

监管及禁止进口产品

分析证书(COA)

输入产品批号来搜索分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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如何查找产品货号

在网站页面上，产品编号会附带包装尺寸/数量一起显示（例如：T1503-25G）。请确保在“产品编号”字段中仅输入产品编号 (示例: T1503).

示例

T1503

货号

25G

包装规格/数量

其它示例：

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

输入内容 1.000309185)

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如何查找COA批号

批号可以在产品标签上"批“ （Lot或Batch）字后面找到。

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如果您查询到的批号为 TO09019TO 等，请输入去除前两位字母的批号：09019TO。
如果您查询到的批号含有填充代码（例如05427ES-021），请输入去除填充代码-021的批号：05427ES。
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索取COA

Simultaneous determination of dexamethasone and betamethasone in pharmaceuticals by reversed-phase HPLC

Pena-Garcia-Brioles D, et al.

Chromatographia, 39(9), 539-542 (1994)

Development and validation of a stability-indicating RP-HPLC method to separate low levels of dexamethasone and other related compounds from betamethasone

Xiong Y, et al.

Journal of Pharmaceutical and Biomedical Analysis, 49(3), 646-654 (2009)

Method development for betamethasone and dexamethasone by micellar liquid chromatography using cetyl trimethyl ammonium bromide and validation in tablets: Application to cocktails

Pena-Garcia-Brioles D, et al.

Journal of Pharmaceutical and Biomedical Analysis, 36(1), 65-71 (2004)

Development and validation of a stability-indicating RP-HPLC method for assay of betamethasone and estimation of its related compounds

Fu Q, et al.

Journal of Pharmaceutical and Biomedical Analysis, 51(3), 617-625 (2010)

Safety and efficacy of calcipotriol plus betamethasone dipropionate gel in the treatment of scalp psoriasis in adolescents 12-17 years of age.

M Gooderham et al.

The British journal of dermatology, 171(6), 1470-1477 (2014-07-02)

Plaque psoriasis has a relatively high prevalence in adolescence, resulting in a significant impact on quality of life, including social interactions. The primary objective was to assess the safety of once-daily application of fixed-combination calcipotriol plus betamethasone dipropionate gel in

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文件

安全信息

倍他米松

Pharmaceutical Secondary Standard; Certified Reference Material

属性

生物来源

质量水平

等级

Agency

蒸汽压

API类

CofA

包装

储存条件

技术

颜色

mp

溶解性

密度

应用

格式

运输

储存温度

SMILES字符串

InChI

InChI key

基因信息

相关类别

说明

一般描述

应用

分析说明

其他说明

附注

相关产品

相关产品

安全信息

象形图

警示用语：

危险声明

预防措施声明

危险分类

储存分类代码

WGK

闪点(°F)

闪点(°C)

法规信息

文件

分析证书(COA)

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