Merck
CN

PHR1402

Supelco

盐酸酚苄明

Pharmaceutical Secondary Standard; Certified Reference Material

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别名:
盐酸酚苄明 盐酸盐, N-(2-氯乙基)-N-(1-甲基-2-苯氧乙基)苄胺 盐酸盐
经验公式(希尔记法):
C18H22ClNO · HCl
CAS号:
分子量:
340.29
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

Agency

traceable to USP 1526007

API family

phenoxybenzamine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

2-30°C

SMILES string

Cl[H].CC(COc1ccccc1)N(CCCl)Cc2ccccc2

InChI

1S/C18H22ClNO.ClH/c1-16(15-21-18-10-6-3-7-11-18)20(13-12-19)14-17-8-4-2-5-9-17;/h2-11,16H,12-15H2,1H3;1H

InChI key

VBCPVIWPDJVHAN-UHFFFAOYSA-N

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一般描述

Phenoxybenzamine Hydrochloride is an important drug belonging to the class of β-chloroethylamine drugs. It functions as an α-blocker by binding to α-adrenoreceptors, located on vascular smooth muscles and stops the influence of sympathetic nerves on blood vessels. It is widely used in the treatment of hypertension, benign prostatic hyperplasia and hypoplastic left heart syndrome.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

应用

Phenoxybenzamine Hydrochloride may be used as a pharmaceutical reference standard in the determination of the analyte in pharmaceutical formulations by chromatographic and chemiluminescence techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生化/生理作用

钙调蛋白拮抗剂;α-肾上腺素受体拮抗剂。

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAA2196 in the slot below. This is an example certificate only and may not be the lot that you receive.

象形图

Exclamation markHealth hazard

警示用语:

Warning

危险声明

危险分类

Acute Tox. 4 Oral - Carc. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


分析证书(COA)

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示例

T1503
货号
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25G
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1000309185

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批号可以在产品标签上"批“ (Lot或Batch)字后面找到。

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索取COA

Sensitive chemiluminescence determination of phentolamine mesylate and phenoxybenzamine hydrochloride based on K3Fe (CN) 6-H2O2-fluorescein
Xing L, et al.
Journal of Luminescence, 137(38), 162-167 (2013)
A facile enantioselective synthesis of enantiomerically pure (R)-phenoxybenzamine hydrochloride using the hydrolytic kinetic resolution method
Nikalje MD, et al.
Tetrahedron Asymmetry, 21(23), 2825-2829 (2010)
Quantitative gas chromatographic determination of azapetine and phenoxybenzamine in pharmaceutical preparations
Silvestri S and Taponeco G
Journal of Chromatography A, 37(38), 200-204 (1968)
Chiral aziridine ring opening: facile synthesis of (R)-mexiletine and (R)-phenoxybenzamine hydrochloride
Viswanadh N, et al.
Tetrahedron Letters, 56(38), 5269-5271 (2015)
Phenoxybenzamine and phenoxybenzamine hydrochloride.
IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, 24, 185-194 (1980-01-01)

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