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Merck
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PHR1527

醋酸地塞米松

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

地塞米松 21-乙酸酯, 9α-氟-16α-甲基-11β,17α,21-三羟基--1,4-孕甾二烯-3,20-二酮-21-乙酸酯, 9α-氟-16α-甲基氢化泼尼松龙-21-乙酸酯, 泼尼松龙乙酸酯

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关于此项目

经验公式（希尔记法）:
C24H31FO6
化学文摘社编号:
1177-87-3
分子量:
434.50
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823439
EC Number:
214-646-8
Beilstein/REAXYS Number:
2342608
MDL number:
MFCD00027407

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产品名称

醋酸地塞米松, Pharmaceutical Secondary Standard; Certified Reference Material

InChI key

AKUJBENLRBOFTD-RPRRAYFGSA-N

InChI

1S/C24H31FO6/c1-13-9-18-17-6-5-15-10-16(27)7-8-21(15,3)23(17,25)19(28)11-22(18,4)24(13,30)20(29)12-31-14(2)26/h7-8,10,13,17-19,28,30H,5-6,9,11-12H2,1-4H3/t13-,17+,18+,19+,21+,22+,23+,24+/m1/s1

SMILES string

[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@@]4(C)[C@@]2([H])C[C@@H](C)[C@]4(O)C(=O)COC(C)=O

biological source

synthetic

grade

certified reference material
pharmaceutical secondary standard

agency

EP
USP
traceable to Ph. Eur. D0710000
traceable to USP 1176506

vapor pressure

<0.0000001 kPa ( 25 °C)

API family

dexamethasone

CofA

current certificate can be downloaded

packaging

pkg of 1 g

storage condition

protect from light (20 mm aluminium crimp seal for unused portion)

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

color

white

mp

460.4-464 °F (238—240°C)

solubility

acetone: freely soluble
dichloromethane: slightly soluble
methanol: freely soluble
water: practically insoluble

application(s)

pharmaceutical (small molecule)

format

neat

shipped in

ambient

storage temp.

2-30°C

Quality Level

300

Gene Information

human ... NR3C1(2908)

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Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Application

Dexamethasone Acetate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.
Dexamethasone acetate is used as a pharmaceutical reference standard for the quantification the analyte in pharmaceutical formulations using liquid chromatography (LC) technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Dexamethasone acetate (Decadron-LA) belongs to the class of long-acting glucocorticoids. Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Dexamethasone Acetate is a steroid used for the treatment of various diseases because of its anti-inflammatory and inmunosuppresor effects. It is a common component of ointments, creams, lotions, aerosols and microemulsions.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA3645 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360FD

Hazard Classifications

Repr. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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Determination of dexamethasone acetate in cream by HPLC.
Garcia CV, et al.
Journal of Pharmaceutical and Biomedical Analysis, 31(3), 597-600 (2003)
Development and validation of HPLC method for analysis of dexamethasone acetate in microemulsions.
Urban MCC, et al.
Brazilian Journal of Pharmaceutical Sciences , 45(1), 87-92 (2009)
Dexamethasone
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 10(3), 4961-4963 (2021)
Daniele de Paula Faria et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 55(8), 1330-1335 (2014-06-11)
The experimental autoimmune encephalomyelitis model is a model of multiple sclerosis that closely mimics the disease characteristics in humans. The main hallmarks of multiple sclerosis are neuroinflammation (microglia activation, monocyte invasion, and T-cell infiltration) and demyelination. PET imaging may be
Dunja Drakulić et al.
Journal of molecular neuroscience : MN, 55(4), 959-967 (2014-11-05)
Although dexamethasone (DEX), a synthetic glucocorticoid receptor (GR) analog with profound effects on energy metabolism, immune system, and hypothalamic-pituitary-adrenal axis, is widely used therapeutically, its impact on the brain is poorly understood. The aim of the present study was to

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