PHR1678
比卡鲁胺
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
比卡鲁胺 (CDX), N-[4-氰基-3-(三氟甲基)苯基]-3-(4-氟苯硫酰基)-2-甲基-2-羟基丙酰胺, 比卡他胺, 比卡胺
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经验公式（希尔记法）:
C18H14F4N2O4S
化学文摘社编号:
分子量:
430.37
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
产品名称
比卡鲁胺, Pharmaceutical Secondary Standard; Certified Reference Material
InChI key
LKJPYSCBVHEWIU-UHFFFAOYSA-N
SMILES string
CC(O)(CS(=O)(=O)c1ccc(F)cc1)C(=O)Nc2ccc(C#N)c(c2)C(F)(F)F
InChI
1S/C18H14F4N2O4S/c1-17(26,10-29(27,28)14-6-3-12(19)4-7-14)16(25)24-13-5-2-11(9-23)15(8-13)18(20,21)22/h2-8,26H,10H2,1H3,(H,24,25)
grade
certified reference material
pharmaceutical secondary standard
agency
traceable to Ph. Eur. Y0001444
traceable to USP 1071202
API family
bicalutamide
CofA
current certificate can be downloaded
packaging
pkg of 1 g
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
Quality Level
Gene Information
human ... AR(367)
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Biochem/physiol Actions
比卡鲁胺 (CDX) 是一种非杀菌的雄激素受体 (AR) 拮抗剂，是纯抗雄激素。它通过平衡组蛋白乙酰化/去乙酰化和共调剂募集发挥作用。比卡鲁胺(CDX)消除了雄激素介导的表达。例如，前列腺癌、PLZF（早幼粒细胞白血病锌指蛋白）和GADD45γ中的MMP13上调（生长停滞和可诱导的DNA损伤，γ）。通过雄激素，对PI3K /AKT磷酸化进行非基因组、非转录依赖性刺激，抑制比卡鲁胺(CDX)。
比卡鲁胺(CDX)是一种非杀菌性雄激素受体 (AR) 拮抗剂，是一种纯雄激素抗体。
Analysis Note
These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.
Application
Bicalutamide may be used as a pharmaceutical reference standard for the determination of the analyte by high performance liquid chromatography and UV spectrophotometry.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
General description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Bicalutamide is a non-steroidal peripheral androgen receptor inhibitor. Its mode of action involves inhibiting androgen by binding to cytosol androgen receptors in the target tissue.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA6123 in the slot below. This is an example certificate only and may not be the lot that you receive.
signalword
Danger
hcodes
Hazard Classifications
Aquatic Chronic 1 - Carc. 2 - Repr. 1B
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Determination and validation of UV spectrophotometric method for estimation of bicalutamide tablet
Swamivelmanickam M, et al,.
International Journal of ChemTech Research, 1(4), 1189-1193 (2009)
Development and validation of a stability indicating HPLC Method for determination of Bicalutamide in pharmaceutical formulations
Reddy GNK, et al.
International Journal of Pharmacy and Biological Sciences, 2(4), 134-149 (2012)
Development and validation of RP-HPLC method for the estimation of Bicalutamide in pure and pharmaceutical dosage forms
Rao AL, et al.
Rasayan Journal of Chemistry, 2(2), 512-515 (2009)
Development of an electrochemical method for the determination of bicalutamide at the SWCNT/CPE in pharmaceutical preparations and human biological fluids
Pandit UJ, et al.
Analytical Methods : Advancing Methods and Applications, 7(24), 10192-10198 (2015)
Emiliano Ventura et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 37(8), 1253-1263 (2020-05-14)
Selective androgen receptor modulators (SARMs) are a class of new emerging "designer" steroid compounds gaining popularity over more well established anabolic-androgenic steroids (AAS) amongst both non-professional and elite athletes. Moreover, due to their anabolic activity, SARM compounds may also potentially
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