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Merck
CN

PHR3069

奥洛他定 盐酸盐

pharmaceutical secondary standard, certified reference material

别名:

(11Z)-11- [3-（二甲氨基）亚丙基]-6,11-二氢二苯并 [b,e] 氧杂萘-2-乙酸 盐酸盐, AL-4943A, KW-4679, 奥洛他定, 帕坦诺

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关于此项目

经验公式（希尔记法）:
C21H23NO3·HCl
化学文摘社编号:
140462-76-6
分子量:
373.87
UNSPSC Code:
41116107
NACRES:
NA.24
MDL number:
MFCD00875716

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产品名称

奥洛他定 盐酸盐, pharmaceutical secondary standard, certified reference material

InChI

1S/C21H23NO3.ClH/c1-22(2)11-5-8-18-17-7-4-3-6-16(17)14-25-20-10-9-15(12-19(18)20)13-21(23)24;/h3-4,6-10,12H,5,11,13-14H2,1-2H3,(H,23,24);1H/b18-8-;

SMILES string

Cl.CN(C)CC\C=C1\c2ccccc2COc3ccc(CC(O)=O)cc13

InChI key

HVRLZEKDTUEKQH-NOILCQHBSA-N

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to USP 1478403

CofA

current certificate can be downloaded

packaging

pkg of 300 mg

application(s)

pharmaceutical

Quality Level

300

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相关类别

Biochem/physiol Actions

奥洛他定是一种双效组胺 H1 受体拮抗剂和肥大细胞稳定剂。
奥洛他定是一种组胺 H1 受体拮抗剂和肥大细胞稳定剂。大脑中的 H1 受体占位级别较低解释了奥洛他定镇静作用较低的原因。一般认为奥洛他定是 P-糖蛋白的底物，限制了其脑渗透。

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA6959(changes by product) in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

signalword

Danger

hcodes

H301,H400

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

分析证书(COA)

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