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Merck
CN

S0252

磺溴酞 二钠盐 水合物

used to study hepatocyte transport functions

别名:

BSP, 溴磺胺钠 二钠盐 水合物

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关于此项目

经验公式(希尔记法):
C20H8Br4Na2O10S2 · xH2O
化学文摘社编号:
分子量:
838.00 (anhydrous basis)
NACRES:
NA.47
PubChem Substance ID:
UNSPSC Code:
12171500
EC Number:
200-761-0
MDL number:
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产品名称

磺溴酞 二钠盐 水合物, used to study hepatocyte transport functions

InChI key

CDTNUNQQEUGDSD-UHFFFAOYSA-L

InChI

1S/C20H10Br4O10S2.2Na.H2O/c21-15-13-14(16(22)18(24)17(15)23)20(34-19(13)27,7-1-3-9(25)11(5-7)35(28,29)30)8-2-4-10(26)12(6-8)36(31,32)33;;;/h1-6,25-26H,(H,28,29,30)(H,31,32,33);;;1H2/q;2*+1;/p-2

SMILES string

[Na+].[Na+].[H]O[H].Oc1ccc(cc1S([O-])(=O)=O)C2(OC(=O)c3c(Br)c(Br)c(Br)c(Br)c23)c4ccc(O)c(c4)S([O-])(=O)=O

form

powder

composition

Water (by Karl Fischer): ≤ 8%

Sodium (Na) anhydrous: 4.6-5.8%

technique(s)

titration: suitable

color

white to light gray

λmax

575-581 nm

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

Quality Level

solubility

water: 50 mg/mL (clear to very hazy)

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Application

磺溴酞二钠盐水合物已用作阳性对照,以研究11-酮-β-乳香酸(KBA)和3-乙酰基-11-酮-β-乳香酸(AKBA)与有机阴离子转运蛋白OATP1B3的相互作用。

Biochem/physiol Actions

磺溴酞(BSP)是有机阴离子转运多肽(OATP)的高亲和力有机离子底物,已被用作多药耐药相关蛋白2(Mrp2)的底物。BSP通过OATP转运到肝细胞中,与谷胱甘肽结合后,通过MRP2排泄到胆汁中。发现它抑制醛酮还原酶ARK1C20。

pictograms

Health hazard

signalword

Danger

hcodes

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Organic Anion Transporting Polypeptide Mediates Organic Anion/HCO3- Exchange*
Lisa M
The Journal of Biological Chemistry (1997)
Permeation of Boswellia extract in the Caco-2 model and possible interactions of its constituents KBA and AKBA with OATP1B3 and MRP2
Philip Kruger
European Journal of Pharmaceutical Sciences, 36 (2009)
Napo K M Cheung et al.
PLoS genetics, 13(12), e1007123-e1007123 (2017-12-22)
The heavily methylated vertebrate genomes are punctuated by stretches of poorly methylated DNA sequences that usually mark gene regulatory regions. It is known that the methylation state of these regions confers transcriptional control over their associated genes. Given its governance
Induction of multidrug resistance-associated protein 2 in liver, intestine and kidney of streptozotocin-induced diabetic rats.
Xenobiotica, 42(8) (2012)
Ling-Tao Zhang et al.
Life sciences, 232, 116669-116669 (2019-07-22)
This study investigated the effects of hyaluronic acid (HA), a commonly used osteogenic medium referred to as DAG, and the combined administration of HA and DAG (CG) on the osteogenic differentiation of human amniotic mesenchymal stem cells (hAMSCs), and the

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