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Merck
CN

S0252

磺溴酞 二钠盐 水合物

used to study hepatocyte transport functions

别名:

BSP, 溴磺胺钠 二钠盐 水合物

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关于此项目

经验公式（希尔记法）:
C20H8Br4Na2O10S2 · xH2O
化学文摘社编号:
123359-42-2
分子量:
838.00 (anhydrous basis)
NACRES:
NA.47
PubChem Substance ID:
24899433
UNSPSC Code:
12171500
EC Number:
200-761-0
MDL number:
MFCD00150017

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InChI key

CDTNUNQQEUGDSD-UHFFFAOYSA-L

InChI

1S/C20H10Br4O10S2.2Na.H2O/c21-15-13-14(16(22)18(24)17(15)23)20(34-19(13)27,7-1-3-9(25)11(5-7)35(28,29)30)8-2-4-10(26)12(6-8)36(31,32)33;;;/h1-6,25-26H,(H,28,29,30)(H,31,32,33);;;1H2/q;2*+1;/p-2

SMILES string

[Na+].[Na+].[H]O[H].Oc1ccc(cc1S([O-])(=O)=O)C2(OC(=O)c3c(Br)c(Br)c(Br)c(Br)c23)c4ccc(O)c(c4)S([O-])(=O)=O

form

powder

composition

Water (by Karl Fischer): ≤ 8%

Sodium (Na) anhydrous: 4.6-5.8%

technique(s)

titration: suitable

color

white to light gray

λmax

575-581 nm

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

Quality Level

200

solubility

water: 50 mg/mL (clear to very hazy)

相关类别

Application

磺溴酞二钠盐水合物已用作阳性对照，以研究11-酮-β-乳香酸（KBA）和3-乙酰基-11-酮-β-乳香酸（AKBA）与有机阴离子转运蛋白OATP1B3的相互作用。

Biochem/physiol Actions

磺溴酞（BSP）是有机阴离子转运多肽（OATP）的高亲和力有机离子底物，已被用作多药耐药相关蛋白2（Mrp2）的底物。BSP通过OATP转运到肝细胞中，与谷胱甘肽结合后，通过MRP2排泄到胆汁中。发现它抑制醛酮还原酶ARK1C20。

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H317,H334

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SHBS8512
SHBR4273
SHBP9196
SHBN0832
SHBL8816

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