S0252
磺溴酞 二钠盐 水合物
used to study hepatocyte transport functions
别名:
BSP, 溴磺胺钠 二钠盐 水合物
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关于此项目
经验公式（希尔记法）:
C20H8Br4Na2O10S2 · xH2O
化学文摘社编号:
分子量:
838.00 (anhydrous basis)
NACRES:
NA.47
PubChem Substance ID:
UNSPSC Code:
12171500
EC Number:
200-761-0
MDL number:
Quality Level
form
powder
composition
Water (by Karl Fischer): ≤ 8%
Sodium (Na) anhydrous: 4.6-5.8%
technique(s)
titration: suitable
color
white to light gray
solubility
water: 50 mg/mL (clear to very hazy)
λmax
575-581 nm
application(s)
diagnostic assay manufacturing
hematology
histology
storage temp.
room temp
SMILES string
[Na+].[Na+].[H]O[H].Oc1ccc(cc1S([O-])(=O)=O)C2(OC(=O)c3c(Br)c(Br)c(Br)c(Br)c23)c4ccc(O)c(c4)S([O-])(=O)=O
InChI
1S/C20H10Br4O10S2.2Na.H2O/c21-15-13-14(16(22)18(24)17(15)23)20(34-19(13)27,7-1-3-9(25)11(5-7)35(28,29)30)8-2-4-10(26)12(6-8)36(31,32)33;;;/h1-6,25-26H,(H,28,29,30)(H,31,32,33);;;1H2/q;2*+1;/p-2
InChI key
CDTNUNQQEUGDSD-UHFFFAOYSA-L
Application
磺溴酞二钠盐水合物已用作阳性对照，以研究11-酮-β-乳香酸（KBA）和3-乙酰基-11-酮-β-乳香酸（AKBA）与有机阴离子转运蛋白OATP1B3的相互作用。
Biochem/physiol Actions
磺溴酞（BSP）是有机阴离子转运多肽（OATP）的高亲和力有机离子底物，已被用作多药耐药相关蛋白2（Mrp2）的底物。BSP通过OATP转运到肝细胞中，与谷胱甘肽结合后，通过MRP2排泄到胆汁中。发现它抑制醛酮还原酶ARK1C20。
signalword
Danger
hcodes
Hazard Classifications
Resp. Sens. 1 - Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Substrate- and pH-specific antifolate transport mediated by organic anion-transporting polypeptide 2B1 (OATP2B1-SLCO2B1).
Visentin M
Molecular Pharmaceutics, 81(2), 134-142 (2012)
Jing-Dong Zhou et al.
Journal of cellular and molecular medicine, 21(8), 1468-1481 (2017-04-30)
Promoter hypermethylation-mediated inactivation of ID4 plays a crucial role in the development of solid tumours. This study aimed to investigate ID4 methylation and its clinical relevance in myeloid malignancies. ID4 hypermethylation was associated with higher IPSS scores, but was not
Organic Anion Transporting Polypeptide Mediates Organic Anion/HCO3- Exchange*
Lisa M
The Journal of Biological Chemistry (1997)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| S0252-100G | 04061834990628 |
| S0252-25G | 04061831998641 |
| S0252-1G | 04061834990673 |
| S0252-5G | 04061836830151 |