S0765000
双氯芬酸钠
European Pharmacopoeia (EP) Reference Standard
别名:
双氯芬酸钠 钠盐, 2-[（2,6-二氯苯基）氨基]苯乙酸 钠盐
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经验公式（希尔记法）:
C14H10Cl2NNaO2
化学文摘社编号:
分子量:
318.13
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24
等级
pharmaceutical primary standard
API类
diclofenac
制造商/商品名称
EDQM
技术
HPLC: suitable
gas chromatography (GC): suitable
应用
pharmaceutical (small molecule)
包装形式
neat
SMILES字符串
[Na+].[O-]C(=O)Cc1ccccc1Nc2c(Cl)cccc2Cl
InChI
1S/C14H11Cl2NO2.Na/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;/h1-7,17H,8H2,(H,18,19);/q;+1/p-1
InChI key
KPHWPUGNDIVLNH-UHFFFAOYSA-M
基因信息
human ... PTGS1(5742), PTGS2(5743)
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一般描述
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
应用
Diclofenac sodium EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
生化/生理作用
标准NSAID和环加氧酶（COX）抑制剂。主要代谢物是4′-羟基二苯甲酸和5′-羟基二氯芬酸。已被用作CYP2C9的选择性底物。
包装
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
其他说明
Sales restrictions may apply.
警示用语：
Danger
危险分类
Acute Tox. 3 Oral - Aquatic Chronic 2 - Repr. 2 - STOT RE 1
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Rachel P L van Swelm et al.
Toxicology and applied pharmacology, 269(2), 141-149 (2013-03-20)
Diclofenac (DF) is a widely used non-steroidal anti-inflammatory drug for the treatment of rheumatic disorders, but is often associated with liver injury. We applied urinary proteomic profiling using MALDI-TOF MS to identify biomarkers for DF-induced hepatotoxicity in mice. Female CH3/HeOUJIco
Shahinaze A Fouad et al.
International journal of pharmaceutics, 453(2), 569-578 (2013-06-26)
Microemulsion (ME) and poloxamer microemulsion-based gel (PMBG) were developed and optimized to enhance transport of diclofenac epolamine (DE) into the skin forming in-skin drug depot for sustained transdermal delivery of drug. D-optimal mixture experimental design was applied to optimize ME
Dong Qing Zhang et al.
Environmental pollution (Barking, Essex : 1987), 181, 98-106 (2013-07-13)
A systematic approach to assess the fate of selected pharmaceuticals (carbamazepine, naproxen, diclofenac, clofibric acid and caffeine) in hydroponic mesocosms is described. The overall objective was to determine the kinetics of depletion (from solution) and plant uptake for these compounds
R E Small
Clinical pharmacy, 8(8), 545-558 (1989-08-01)
The pharmacology, pharmacokinetics, clinical efficacy, adverse effects, and dosage of diclofenac sodium are reviewed. Diclofenac, the first nonsteroidal anti-inflammatory agent (NSAID) to be approved that is a phenylacetic acid derivative, competes with arachidonic acid for binding to cyclo-oxygenase, resulting in
L K Dodgen et al.
Environmental pollution (Barking, Essex : 1987), 182, 150-156 (2013-08-06)
Many pharmaceutical and personal care products (PPCPs) and endocrine-disrupting chemicals (EDCs) are present in reclaimed water, leading to concerns of human health risks from the consumption of food crops irrigated with reclaimed water. This study evaluated the potential for plant
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