产品名称
丙戊酸钠, European Pharmacopoeia (EP) Reference Standard
InChI
1S/C8H16O2.Na/c1-3-5-7(6-4-2)8(9)10;/h7H,3-6H2,1-2H3,(H,9,10);/q;+1/p-1
SMILES string
[Na+].CCCC(CCC)C([O-])=O
InChI key
AEQFSUDEHCCHBT-UHFFFAOYSA-M
grade
pharmaceutical primary standard
API family
sodium valproate
manufacturer/tradename
EDQM
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
Gene Information
human ... ALDH5A1(7915)
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Repr. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Kristen A Wellmann et al.
Brain research bulletin, 108, 1-9 (2014-08-19)
Prenatal exposure to valproic acid (VPA) alters rodent social interactions in a dose-dependent way: exposure to a high dose of VPA (>500 mg/kg) mid-gestation decreases social interactions whereas a moderate dose of VPA (350 mg/kg) increases peer-directed social behavior. The
Péter Pelsőczi et al.
Frontiers in behavioral neuroscience, 13, 295-295 (2020-02-06)
Autism spectrum disorder (ASD) is characterized by impaired socio-communicational function, repetitive and restricted behaviors. Valproic acid (VPA) was reported to increase the prevalence of ASD in humans as a consequence of its use during pregnancy. VPA treatment also induces autistic-like
Pengfei Shi et al.
BMC cancer, 14, 370-370 (2014-06-03)
Valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, is reported to exert anti-tumor effects by upregulating the expression of the natural killer group 2D (NKG2D) ligands on tumor cells; however, the mechanisms vary in different tumor types, and the effect
Peter Štefánik et al.
Pharmacology, biochemistry, and behavior, 131, 42-50 (2015-02-11)
Autism is a neurodevelopmental disorder characterised by the disruption of social interactions. Autistic animal models play a crucial role in neurophysiologic research on this disorder. One of these models is based on rats that have been prenatally treated with valproic
Osvaldo Garrido-Acosta et al.
Journal of pharmacological and toxicological methods, 70(1), 66-69 (2014-05-27)
We determined the median effective dose (ED50) values for the anticonvulsants phenobarbital and sodium valproate using a modification of Lorke's method. This modification allowed appropriate statistical analysis and the use of a smaller number of mice per compound tested. The
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