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文件

T2200000

甲氧苄啶

European Pharmacopoeia (EP) Reference Standard

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别名:
2,4-二氨基-5-(3,4,5-三甲氧基苄基)嘧啶, NSC 106568
经验公式（希尔记法）:
C14H18N4O3
CAS号:
738-70-5
分子量:
290.32
Beilstein:
625127
MDL编号:
MFCD00036761
PubChem化学物质编号:
329826703
NACRES:
NA.24

等级

pharmaceutical primary standard

API类

trimethoprim

制造商/商品名称

EDQM

应用

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

SMILES字符串

COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC

InChI

1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)

InChI key

IEDVJHCEMCRBQM-UHFFFAOYSA-N

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相关类别

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

应用

主要作为抗细菌剂。 二氢叶酸还原酶抑制活性和原核酶选择性。

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

象形图

Exclamation markHealth hazard
GHS07,GHS08

警示用语：

Warning

危险声明

H302 - H361d

危险分类

Acute Tox. 4 Oral - Repr. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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示例

T1503
货号
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25G
包装规格/数量

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705578-5MG-PW

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O Sköld
Veterinary research, 32(3-4), 261-273 (2001-07-04)
Sulfonamides and trimethoprim have been used for many decades as efficient and inexpensive antibacterial agents for animals and man. Resistance to both has, however, spread extensively and rapidly. This is mainly due to the horizontal spread of resistance genes, expressing
Christine Manyando et al.
PloS one, 9(5), e96017-e96017 (2014-05-17)
Antibiotic therapy during pregnancy may be beneficial and impacts positively on the reduction of adverse pregnancy outcomes. No studies have been done so far on the effects of daily Co-trimoxazole (CTX) prophylaxis on birth outcomes. A phase 3b randomized trial
Karin Tegmark Wisell et al.
The Journal of antimicrobial chemotherapy, 62(1), 35-40 (2008-04-15)
The lack of oral treatment alternatives for enterococcal urinary tract infections (UTIs) has led to a renewed interest in trimethoprim. Enterococci can incorporate exogenously produced folates and thereby reverse the effect of trimethoprim. Although a large proportion of enterococci appear
Luis H Braga et al.
The Journal of urology, 191(5 Suppl), 1501-1507 (2014-04-01)
We determined the feasibility of a clinical trial of continuous antibiotic prophylaxis to prevent urinary tract infections in children with prenatal hydronephrosis. We piloted a blinded, randomized, placebo controlled study of the urinary tract infection rate in infants with grades
Dolores Camacho-Muñoz et al.
Chemosphere, 111, 70-79 (2014-07-07)
The distribution of pharmaceutically active compounds in the environment has been reported in several works in which wastewater treatment plants have been identified as the main source of these compounds to the environment. The concentrations of these compounds in influent
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