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文件

Y0000458

瑞格列奈

Name: 瑞格列奈
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

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别名:

瑞格列奈, (S)-(+)-2-乙氧基-4- [N- [1-（2-哌啶苯基）-3-甲基-1-丁基] 氨基羰基甲基] 苯甲酸, Novonorm, Prandin

经验公式（希尔记法）:

C₂₇H₃₆N₂O₄

CAS号:

135062-02-1

分子量:

452.59

MDL编号:

MFCD00906179

PubChem化学物质编号:

329830968

NACRES:

NA.24

等级

pharmaceutical primary standard

API family

repaglinide

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

SMILES string

CCOc1cc(CC(=O)N[C@@H](CC(C)C)c2ccccc2N3CCCCC3)ccc1C(O)=O

InChI

1S/C27H36N2O4/c1-4-33-25-17-20(12-13-22(25)27(31)32)18-26(30)28-23(16-19(2)3)21-10-6-7-11-24(21)29-14-8-5-9-15-29/h6-7,10-13,17,19,23H,4-5,8-9,14-16,18H2,1-3H3,(H,28,30)(H,31,32)/t23-/m0/s1

InChI key

FAEKWTJYAYMJKF-QHCPKHFHSA-N

Gene Information

human ... ABCC8(6833) , KCNJ11(3767)

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一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Repaglinide for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

生化/生理作用

瑞格列奈是一种有效的短效胰岛素促分泌剂，可通过关闭胰岛β细胞质膜中的ATP敏感性钾（K_ATP）通道发挥作用。它是一类新的胰岛素促分泌素，其结构上与磺酰脲无关，专为治疗2型糖尿病而开发。

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

1600824

1600835

1600846

1600868

PHR3129

PHR3131

PHR3408

瑞格列奈, pharmaceutical secondary standard, certified reference material

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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示例

T1503

货号

25G

包装规格/数量

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Oxidative/nitrosative stress and protein damages in aqueous humor of hyperglycemic rabbits: effects of two oral antidiabetics, pioglitazone and repaglinide.

Anna Gumieniczek et al.

Experimental diabetes research, 2012, 653678-653678 (2012-04-05)

The present study was undertaken to determine oxidative/nitrosative stress in aqueous humor of alloxan-induced hyperglycemic rabbits and to investigate the effects of two oral antidiabetic drugs, pioglitazone from peroxisome proliferator-activated receptor gamma (PPARγ) agonists and repaglinide from nonsulfonylurea K(ATP) channel

Preparation, characterization and in vivo evaluation of antihyperglycemic activity of microwave generated repaglinide solid dispersion.

Laxmikant Ramvallabh Zawar et al.

Chemical & pharmaceutical bulletin, 60(4), 482-487 (2012-04-03)

The influence of microwave technology on the in vitro dissolution rate and in vivo antihyperglycemic activity of a poorly water soluble drug, repaglinide (RG) was studied. Solid dispersions were prepared by conventional fusion method and microwave method using poloxamer 188.

Spray-dried gastroretentive floating microparticles: preparation and in vitro evaluation.

Boggarapu Prakash Rao et al.

Pakistan journal of pharmaceutical sciences, 26(4), 707-713 (2013-07-03)

The full factorial design was employed to evaluate contribution of drug: polymer and Eudragit RS 100: Eudragit RL 100 on entrapment efficiency, time for maximum drug release, percentage of drug release. Floating microparticles were prepared using spray drying technique. Microparticles

LC-MS/MS-ESI method for simultaneous quantitation of metformin and repaglinidie in rat plasma and its application to pharmacokinetic study in rats.

Kuldeep Sharma et al.

Biomedical chromatography : BMC, 27(3), 356-364 (2012-08-07)

A highly sensitive and specific LC-MS/MS-ESI method has been developed for simultaneous quantification of metformin (MFN) and repaglinide (RGN) in rat plasma (50 μL) using phenacetin as an internal standard (IS). Simple protein precipitation was used to extract MFN and

Calaxin drives sperm chemotaxis by Ca²⁺-mediated direct modulation of a dynein motor.

Katsutoshi Mizuno et al.

Proceedings of the National Academy of Sciences of the United States of America, 109(50), 20497-20502 (2012-11-22)

Sperm chemotaxis occurs widely in animals and plants and plays an important role in the success of fertilization. Several studies have recently demonstrated that Ca(2+) influx through specific Ca(2+) channels is a prerequisite for sperm chemotactic movement. However, the regulator

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