产品名称
吉西他滨杂质A, European Pharmacopoeia (EP) Reference Standard
InChI
1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
SMILES string
NC1=NC(=O)NC=C1
InChI key
OPTASPLRGRRNAP-UHFFFAOYSA-N
grade
pharmaceutical primary standard
API family
gemcitabine
manufacturer/tradename
EDQM
mp
>300 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
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Application
Gemcitabine impurity A EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Other Notes
Sales restrictions may apply.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Rebecca C Richmond et al.
Human molecular genetics, 24(8), 2201-2217 (2015-01-02)
Maternal smoking during pregnancy has been found to influence newborn DNA methylation in genes involved in fundamental developmental processes. It is pertinent to understand the degree to which the offspring methylome is sensitive to the intensity and duration of prenatal
Yong Liu et al.
Hypertension (Dallas, Tex. : 1979), 63(4), 827-838 (2014-01-15)
Analysis of 5-hydroxymethylcytosine (5hmC) at single-base resolution has been largely limited to studies of stem cells or developmental stages. Given the potential importance of epigenetic events in hypertension, we have analyzed 5hmC and 5-methylcytosine (5mC) at single-base resolution in the
C P Walsh et al.
Current topics in microbiology and immunology, 301, 283-315 (2006-03-31)
Cytosine methylation is a common form of post-replicative DNA modification seen in both bacteria and eukaryotes. Modified cytosines have long been known to act as hotspots for mutations due to the high rate of spontaneous deamination of this base to
Benjamin Delatte et al.
Briefings in functional genomics, 12(3), 191-204 (2013-04-30)
Epigenetic genome marking and chromatin regulation are central to establishing tissue-specific gene expression programs, and hence to several biological processes. Until recently, the only known epigenetic mark on DNA in mammals was 5-methylcytosine, established and propagated by DNA methyltransferases and
Gitali Devi et al.
Nucleic acids research, 42(6), 4008-4018 (2014-01-16)
Peptide nucleic acids (PNAs) have been developed for applications in biotechnology and therapeutics. There is great potential in the development of chemically modified PNAs or other triplex-forming ligands that selectively bind to RNA duplexes, but not single-stranded regions, at near-physiological
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