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文件

Y0000757

(−)-核黄素

Name: (−)-核黄素
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

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别名:

乳黄素, 维生素 B₂, 维生素 G

经验公式（希尔记法）:

C₁₇H₂₀N₄O₆

CAS号:

83-88-5

分子量:

376.36

Beilstein:

97825

MDL编号:

MFCD00005022

PubChem化学物质编号:

329831131

NACRES:

NA.24

生物来源

synthetic

等级

pharmaceutical primary standard

Agency

API family

riboflavin

形式

solid

manufacturer/tradename

EDQM

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

mp

290 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

SMILES string

CC1=C(C)C=C(N(C[C@H](O)[C@@H]([C@H](O)CO)O)C(C2=N3)=NC(NC2=O)=O)C3=C1

InChI

1S/C17H20N4O6/c1-7-3-9-10(4-8(7)2)21(5-11(23)14(25)12(24)6-22)15-13(18-9)16(26)20-17(27)19-15/h3-4,11-12,14,22-25H,5-6H2,1-2H3,(H,20,26,27)/t11-,12+,14-/m0/s1

InChI key

AUNGANRZJHBGPY-SCRDCRAPSA-N

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一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Riboflavin, also known as vitamin B₂, is crucial for human nutrition, and growth. It finds potential applications in biological redox reactions and is found in several foodstuffs, energy drinks, and vitamin formulations.

应用

Riboflavin may be used as an EP reference standard for the determination of the analyte in pharmaceutical formulations by liquid chromatography.

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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示例

T1503

货号

25G

包装规格/数量

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705578-5MG-PW

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1000309185

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索取COA

Riboflavin

European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare

European pharmacopoeia, 5(2), 3484-3485 (2008)

Differential pulse polarographic method development and validation of riboflavin in pharmaceutical formulation

Kashid LM and Patil SV

International Journal of Scientific Research, 5(2), 325-334 (2015)

Simultaneous determination of riboflavin phosphate and other ingredients in a multivitamin pharmaceutical preparation by on-line automated LC coupled with pre-column immobilized enzyme reactor

Ono M, et al.

Journal of Pharmaceutical and Biomedical Analysis, 29(1-2), 325-334 (2002)

The effect of standard and high-fluence corneal cross-linking (CXL) on cornea and limbus.

Olivier Richoz et al.

Investigative ophthalmology & visual science, 55(9), 5783-5787 (2014-07-24)

When treating peripheral ectatic disease-like pellucid marginal degeneration (PMD), corneal cross-linking with UV-A and riboflavin (CXL) must be applied eccentrically to the periphery of the lower cornea, partly irradiating the corneal limbus. Here, we investigated the effect of standard and

Optical coherence tomography and confocal microscopy following three different protocols of corneal collagen-crosslinking in keratoconus.

Nacim Bouheraoua et al.

Investigative ophthalmology & visual science, 55(11), 7601-7609 (2014-10-30)

We compared the efficacy and early morphological changes in the cornea following conventional (C-CXL), transepithelial by iontophoresis (I-CXL), and accelerated (A-CXL) collagen cross-linking in keratoconus. A total of 45 eyes of 45 patients with progressive keratoconus who underwent corneal collagen

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